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Fungi in water pose great risk to immune-compromised individuals

24 July 2023 | Story André Damons | Photo Supplied

Yeast and other filamentous fungi, which pose a great risk to the health of immune-compromised or suppressed individuals, can be found in various drinking water sources such as ground, spring, surface, and tap water. These opportunistic pathogens may cause severe to fatal infections and can range from superficial to bloodstream or systemic infections.

This is according to Tyla Baker, a postgraduate student in the Department of Microbiology and Biochemistry at the University of the Free State (UFS). She is studying for her MSc degree in Microbiology under the supervision Prof Carlien Pohl-Albertyn, National Research Forum (NRF) SARChI Research Chair in Pathogenic Yeasts. Prof Jacobus Albertyn and Dr Jolly Musoke are her co-supervisors.

Baker says the fungi in the water highlights that current water treatment processes are not efficient in their removal from water destined for household use. “These infections may not be harmful to people with healthy immune systems, but do pose a great risk to the health of immune-compromised or suppressed individuals.

Definite possibility to contract fungal infections from polluted water

“As the number of people with immune systems that are less functional (e.g. premature babies, elderly persons, people with cancer, diabetes or other serious diseases, HIV+ persons, transplant patients) increases, the number of people at risk of fungal infection also increases,” says Baker.

According to Baker, a previous study done in Brazil has identified yeast in bottled mineral water as well as municipally supplied tap water. The potential risk to contract fungal infections from polluted water sources is a definite possibility but more research is required to fully understand and determine the level of risk and the extent of its effects, she says. In the context of Mangaung, it is a concern that untreated water from sewage works as well as other sewage often leaks into the environment (as evidenced by numerous recent articles in local newspapers). These waters are potential carriers of large numbers of pathogens (including pathogenic yeasts/fungi) that may increase the risk to people coming into contact with it.

Baker says there is a good chance people are consuming these kinds of micro-organisms daily, considering that yeast and other filamentous fungi can also form biofilms inside pipes and spread as the impact of water flow dislodges these cells. “People will not even be aware that they are consuming these micro-organisms, some fungi are considered nuisance microbes and may cause a change in the smell and taste of water which may act as an indicator that the water is contaminated, but tests would be needed to confirm this,” she says.

The effects of consuming these fungi are still a grey area of research since the full extent of the consumption of yeast is still unknown, but there are studies being conducted to elucidate the full impact of this occurrence, says Baker. The risk depends on the immune status of the person, the specific species of yeast/fungus ingested, and the number of cells/spores ingested.

Culture-dependent and independent methods

“It is important to know that many pathogenic yeasts and other fungi are opportunistic pathogens, meaning they infect individuals whose immune systems are compromised due to various reasons such as illness (HIV/AIDS, cancer, TB etc.), undergoing organ transplants or even something as simple as using antimicrobial agents such as antibiotics.

“Taking this into account, along with the HIV/AIDS statistics in South Africa, which has a prevalence rate of 13,7% with approximately 8,2 million people in 2021 living with HIV, these individuals are more susceptible to infection by these opportunistic pathogens. Some of these pathogenic yeasts are also multidrug resistant or show resistance to readily available antifungals, such as fluconazole, which hinders the ability of healthcare professionals to efficiently treat infections to avoid fatal/severe outcomes,” explains Baker.

For her studies, she will be testing for fungi in water by using a combination of culture-dependent and independent methods to try and identify yeast present in wastewater. Baker says culture-dependent techniques will include culturing (growing) yeast on an appropriate medium while culture-independent techniques will include more intricate molecular work in the form of a multiplex PCR (polymerase chain reaction) which will enable her to identify an array of pathogenic yeasts present in samples.

According to Baker, people can stay safe by boiling water before drinking it, although temperatures above 100°C are required to kill most harmful microbes. Regular cleaning of shower heads and faucets help to prevent build-up which may act as a surface to which fungi will attach to and grow. Another way to stay safe is to maintain and regularly inspect water filters for damage and avoid contact with untreated sewage.

News Archive

UFS to award honorary doctorate to Maria Ramos

2004-12-08

The Council of the University of the Free State (UFS) recently approved the awarding of an honorary doctorate to Ms Maria Ramos, Group Chief Executive of Transnet in April 2005. A total of five honorary doctorandi will be honored.

The other doctorandi are Proff Jan Groenewald (D Sc (hc)), Jaap Durand (D Phil (hc)), Sampie Terreblanche (C Dom (hc)) and Anthon Heyns (MD (hc)).

Me Ramos will receive an honorary doctorate in Economics (P hD (Economics) (hc)) for the large contribution she made to the establishment of a prudent fiscal and macro-economic policy in South Africa and hence, to the restoration of the financial credibility of the country in the eyes of domestic and foreign investors. Ms Ramos was the Director General of the National Treasury from 1996-2003.

She obtained the MSc-degree in Economics in 1992 from the University of London and was awarded a British Council Scholarship (Helen Suzman award) in the same year and in 1991. During the early nineties she was among others project leader of the ANC’s Macro-economic Research Group and also a member of the team that negotiated chapters on finance in the interim Constitution of South Africa. She was a research associate at the Centre for the Study of the South African Economy and International Finance at the London School of Economics and also lectured at the Universities of South Africa and the Witwatersrand.

“It is a great privilege for us to honor Ms Ramos and the other doctorandi in their different fields of expertise. This once again serves as an example of the UFS’s policy to give recognition to people who excel and make a difference,” said Prof Frederick Fourie, Rector and Vice-Chancellor of the UFS.

Prof Jan Groenewald will receive an honorary doctorate for his life-long commitment to the establishment and development of Agricultural Economics as a subject field in South Africa and in Africa and his various contributions to the UFS. During his career, Prof Groenewald received various awards among others in 1998 when he received the Stals Prize for Economics from the South African Academy for Science and Art and in 1990 when he received an honorary medal from the South African Society for Agricultural Economics.

Prof Jaap Durand will receive an honorary doctorate in Philosophy for his pioneering work on various fields in the South African society. He obtained his Masters degree in Philosophy from the UFS and contributed to almost 60 articles and collections. Prof Durand has a colourful career as academic manager: from professor in Systematic Theology and dean of the Faculty of Theology at the University of the Western Cape to Deputy Vice-Chancellor of the same university. He was the ombudsman of the University of Stellenbosch from 2002-2003.

Prof Sampie Terreblanche will receive an honorary doctorate in Economics for the important role he played, and is still playing, to keep the debate about and the need for socio-economic and socio-political reform in South Africa going. Prof Terreblanche started his career as a lecturer at the UFS. In 1992 the Stals Prize for Economics was awarded to him by the South African Academy for Science and Art. Prof Terreblanche was also a founding member of ASSET, an organisation addressing the problems of poverty, inequality and social injustice in South Africa.

Prof Anthon Heyns, Chief Executive Officer of the South African National Blood Service, will receive an honorary doctorate in Medicine. Prof Heyns is a well-known international researcher in Hematology and recently received a Centenary Medal from the UFS for his strong role and national prominence as expert and leading figure in establishing and developing Hematology at the UFS. He was the first head of the UFS’s Department of Hematology and is also co-editor of the only Afrikaans hand book of Hematology. He serves among others as a council member and member of the executive management of the South African Medical Research Council. On the international front he serves on at least five committees of the World Health Organisation based in Geneve, Switzerland. He has two honorary appointments as professor respectively at the UFS and University of the Witwatersrand.

Media release
Issued by: Lacea Loader
Media Representative
Tel: (051) 401-2584
Cell: 083 645 2454
E-mail: loaderl.stg@mail.uovs.ac.za
8 December 2004

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