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06 July 2023 | Story Gerda-Marié van Rooyen | Photo Supplied
Prof Ivan Turok and Prof Melanie Walker
Prof Ivan Turok and Prof Melanie Walker.

Two of the University of the Free State (UFS) SARChI Research Chairs have been included in the 2nd edition of Research.com ranking of the best scholars in the field of Social Sciences and Humanities.

Prof Melanie Walker from the UFS Higher Education and Human Development research group and SARChI Chair: Higher Education and Human Development, and Prof Ivan Turok, from the South African National Research Foundation, who hold the Research Chair in Strengthening Urban Economies: People, Place, Production and Policy, are ranked 41st (ranked 5 286 in the world) and 20th (2 825) in South Africa respectively.

According to the Research.com website, the best scientists ranking is a credible list of leading scientists from the field of Social Sciences and Humanities, established by means of a meticulous analysis of 166 880 scholars determined from multiple bibliometric data sources. For this discipline, as many as 15 317 researchers were analysed and their position in the ranking is based on a researcher’s D-index (Discipline H-index), which only includes papers and citation values for an examined discipline.

The success of a community

As a SARChI Chair in Strengthening Urban Economies: People, Place, Production, and Policy, Prof Turok explores how cities can drive economic growth and foster inclusive development in South Africa. His research analyses the factors contributing to the success of certain cities over others and identifies policies and practices that can enhance conditions for citizens and communities

He says this “pleasant surprise” (being ranked 20th in South Africa in the field of Social Sciences and Humanities) follows years of scientific work and writing.

“Research has also been a labour of love and rewarding in itself. It has fuelled my natural curiosity for learning more about the world, and I have had opportunities to visit places and meet people I would never have had otherwise,” says Prof Turok.

What it takes to be a researcher

Although one can learn the required skills and capabilities to be a good researcher, Prof Turok says having a natural yearning for knowledge and an intrinsic curiosity about the real world is helpful to have a long research career. “Careful mentoring and sound teachers are vital to become an effective researcher.”

He firmly believes research should be relevant to the society in which it is located – especially in a developing country like South Africa.

He continues by saying: “It should shed light on and help to understand the major problems and opportunities facing society, using the tools and techniques available to that particular discipline.” This honoured researcher says researchers should inform societies using simple terms and engage in discussions on matters it faces.

“Researchers should be outward-looking and interact constructively with policy-makers and practitioners to improve public policy while maintaining a healthy dose of scepticism about the intentions of the political elite and other powerful interests.”

When analysing the reasons behind varying levels of economic growth and inclusive development among cities, it is crucial to consider a diverse range of indicators. “Relying solely on a few narrow indicators can be misleading," says Prof Turok.

Indicators to take into consideration include: The economic productivity of the city (output per person) and the average income level, the level of employment in relation to the working-age population, which enables individuals to support themselves and their families financially, and the level of investment, which determines future growth, employment, and income levels.

The value of research

Prof Turok suggests that the government could play a significant role in strengthening urban economies and reducing inequalities by devolving more powers and resources to metropolitan municipalities as the effective coordination of housing and transportation investments is crucial for achieving economic growth and social inclusion in cities. He also recommends aligning the programmes and investment projects of provincial authorities and state-owned enterprises (SOEs) with those of the metropolitan areas.

“Currently, there is a disconnect between the activities of many SOEs and the interests of cities. For example, there is a considerable amount of vacant and underused land in well-located urban areas owned by SOEs, which they refuse to transfer to metros for housing purposes (highlighting the relevance of land reform in cities). Another example is the Sector Education and Training Authorities (SETAs), which operate in silos and do not align their training programmes with the needs of employers in cities,” explains Turok.

Being an internationally recognised expert in his field, Prof. Turok is regularly asked to advise esteemed organisations such as the United Nations and the African Development Bank. Prof. Turok, a former finalist for the National Science and Technology Forum (NSTF) Lifetime Achievement Award in 2021, will serve in this significant role until 2025.

Focusing on Education

Prof Walker, a distinguished scholar in the field of education sciences with an A1 rating from the National Research Foundation (NRF) – which funds SARChI – focuses on the profound impact of apartheid on education and civic life. She concentrates on (higher) education, primarily in the Global South, and addresses the intersecting research and practice challenges of decolonisation, methodology, inequalities, and justice.

This former professor of Higher Education at the University of Nottingham currently holds the esteemed position of UFS Distinguished Professor. She has supervised the production of 23 doctoral theses on higher education and human development since 2016. Additionally, she has delivered numerous keynote speeches worldwide and is an acclaimed author of books and journal articles within her area of expertise.

 


 

PHOTO

Left: Prof Ivan Turok, from the South African National Research Foundation, who holds the Research Chair in Strengthening Urban Economies: People, Place, Production and Policy, is ranked 20th (2 825) in South Africa respectively.

Right: Prof Melanie Walker, SARChI Chair: Higher Education and Human Development, is ranked 41st (ranked 5 286 in the world) in the 2nd edition of Research.com ranking of the best scholars in the field of Social Sciences and Humanities.

 


 

News Archive

Research contributes to improving quality of life for cancer patients
2016-11-21

Description: Inorganic Chemistry supervisors  Tags: Inorganic Chemistry supervisors

Inorganic Chemistry supervisors in the Radiopharmacy
Laboratory during the preparation of a typical complex
mixture to see how fast it reacts. Here are, from the left,
front: Dr Marietjie Schutte-Smith, Dr Alice Brink
(both scholars from the UFS Prestige
Scholar Programme), and Dr Truidie Venter (all three
are Thuthuka-funded researchers).
Back: Prof André Roodt and Dr Johan Venter.
Photo: Supplied

Imagine that you have been diagnosed with bone cancer and only have six months to live. You are in a wheelchair because the pain in your legs is so immense that you can’t walk anymore – similar to a mechanism eating your bones from the inside.

You are lucky though, since you could be injected with a drug to control the pain so effective that you will be able to get out of the wheelchair within a day-and-a-half and be able to walk again. Real-life incidents like these provide intense job satisfaction to Prof André Roodt, Head of Inorganic Chemistry at the University of the Free State (UFS). The research, which is conducted by the Inorganic Group at the UFS, contributes greatly to the availability of pain therapy that does not involve drugs, but improves the quality of life for cancer patients.

The research conducted by the Inorganic Group under the leadership of Prof Roodt, plays a major role in the clever design of model medicines to better detect and treat cancer.

The Department of Chemistry is one of approximately 10 institutions worldwide that conducts research on chemical mechanisms to identify and control cancer. “The fact that we are able to cooperate with the Departments of Nuclear Medicine and Medical Physics at the UFS, the Animal Research Centre, and other collaborators in South Africa and abroad, but especially the methodology we utilise to conduct research (studying the chemical manner in which drugs are absorbed in cancer as well as the time involved), enhances the possibility of making a contribution to cancer research,” says Prof Roodt.

Technique to detect cancer spots on bone
According to the professor, there are various ways of detecting cancer in the body. Cancer can, inter alia, be identified by analysing blood, X-rays (external) or through an internal technique where the patient is injected with a radioactive isotope.

Prof Roodt explains: “The doctor suspects that the patient has bone cancer and injects the person with a drug consisting of an isotope (only emits X-rays and does no damage to tissue) that is connected to a phosphonate (similar to those used for osteoporosis). Once the drug is injected, the isotope (Technetium-99m) moves to the spot on the bone where the cancer is located. The gamma rays in the isotope illuminate the area and the doctor can see exactly where treatment should be applied. The Technetium-99m has the same intensity gamma rays as normal X-rays and therefore operates the same as an internal X-ray supply.” With this technique, the doctor can see where the cancer spots are within a few hours.

The same technique can be used to identify inactive parts of the brain in Alzheimer patients, as well as areas of the heart where there is no blood supply or where the heart muscle is dead.

Therapeutic irradiation of cancer
For the treatment of pain connected with cancer, the isotope Rhenium-186 is injected. Similar to the manner in which the Technetium-99m phosphonate compound is ingested into the body, the Rhenium-186 phosphonate travels to the cancer spots. Patients thus receive therapeutic irradiation – a technique known as palliative therapy, which is excellent for treating pain. A dosage of this therapy usually lasts for about two months.

The therapy is, however, patient specific. The dosages should correspond with the occurrence and size of cancer spots in the patient’s body. First, the location of the cancer will be determined by means of a technetium scan. After that, the size of the area where the cancer occurs has to be determined. The dosage for addressing total pain distribution will be calculated according to these results.

Technique to detect cancer spots on soft tissue
Another technique to detect cancer as spots on bone or in soft tissue and organs throughout the body is by utilising a different type of irradiation, a so-called PET isotope. The Fluor-18 isotope is currently used widely, and in Pretoria a machine called a cyclotron was produced by Dr Gerdus Kemp, who is a former PhD graduate from the Inorganic Research Group. The F-18 is then hidden within a glucose molecule and a patient will be injected with the drug after being tranquillised and after the metabolism has been lowered considerably. The glucose, which is the ‘food' that cancer needs to grow, will then travel directly to the cancer area and the specific area where the cancer is located will thus be traced and ‘illuminated’ by the Fluor-18, which emits its own 'X-rays'.

In the late 80s, Prof Roodt did his own postdoctoral study on this research in the US. He started collaborating with the Department of Nuclear Medicine at the UFS in the early 90s, when he initiated testing for this research.

Through their research of more than 15 years, the Inorganic Group in the Department of Chemistry has made a major contribution to cancer research. Research on mechanisms for the detection of cancer, by designing new clever chemical agents, and the chemical ways in which these agents are taken up in the body, especially contributes to the development in terms of cancer therapy and imaging, and has been used by a number of hospitals in South Africa.

The future holds great promise
Prof Roodt and his team are already working on a bilateral study between the UFS and Kenya. It involves the linking of radio isotopes, as mentioned above, to known natural products (such as rooibos tea), which possess anti-cancer qualities.

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