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27 June 2023 | Story Valentino Ndaba | Photo Charl Devenish
Discussing the Africa We Want
Discussing the Africa we want, were from the left: Shelton Makore (Senior Mercantile Law Lecturer), Prof Danie Brand (Director of the Free State Centre for Human Rights), Ntando Sindane (Private Law Lecturer), and Dr Isolde de Villiers (Senior Mercantile Law Lecturer).

“The Africa we want can only be achieved by promoting good governance, democracy, respect for human rights, justice and the rule of law, a peaceful and secure Africa with a strong cultural identity, common heritage, values, and ethics,” said Shelton Makore, Senior Law Lecturer in the University of the Free State Department of Mercantile Law.

He further remarked that, “Such an approach will enable Africa to have economic, political, and social development that is people-driven, relying on the potential offered by the people of Africa, especially its women and youth, caring for children, and an Africa that is strong, united, resilient, and an influential global player and partner.”

Makore's statement encapsulated a concise summary of the dialogue he moderated, which took place during Africa Month and was organised by the Faculty of Law. The main purpose of the dialogue was to delve into the African Union's Agenda 2063, titled ‘The Africa we want’, with a specific focus on advancing justice in Africa to achieve sustainable development. The discussions revolved around the idea of fostering a politically united and integrated continent that embraces the principles of Pan-Africanism and the vision of African Renaissance.

Looking back on Africa Month

The Faculty of Law hosted a two-tier Africa Day event on the Bloemfontein Campus on 25 May 2023. It included a round-table dialogue on 'Advancing Justice with a View of the Future: The 2063 Agenda for Sustainable Development' and a cultural exhibition titled: 'Appreciating Knowledge through Culture'.

Prof Danie Brand, Director of the Free State Centre for Human Rights at the UFS, Ntando Sindane, Lecturer in the Department of Private Law, and Dr Isolde de Villiers, Senior Lecturer in the Department of Mercantile Law, were part of the panel of experts who facilitated a discussion that looked through the lens of seven aspirational themes:

  • A prosperous Africa, based on inclusive growth and sustainable development
  • An integrated continent, politically united and based on the ideals of Pan-Africanism and the vision of African Renaissance
  • An Africa of good governance, democracy, respect for human rights, justice, and the rule of law
  • A peaceful and secure Africa
  • Africa with a strong cultural identity, common heritage, values, and ethics
  • An Africa whose development is people-driven, relying on the potential offered by African people, especially its women and youth, and caring for children
  • An Africa as a strong, united, resilient, and influential global player and partner

Africa’s futureEnvisioning

During the discussion, Prof Brand underscored the importance of fostering cultural diversity as a means to achieve inclusivity and a sustainable future. On the other hand, Sindane highlighted the necessity of engaging in self-reflection and adapting to the challenges posed by neoliberal and neo-colonial economic structures, aiming to address poverty, hunger, and deprivation in Africa. The panellists delved into a comprehensive exploration of the Sustainable Development Goals and their significant role in shaping the desired future for Africa. Dr De Villiers highlighted the impact of spatial injustice on people's lives, emphasising the need for fair and equitable distribution of resources and opportunities within cities and towns.

The dialogue generated valuable insights on repositioning Africa as a beacon of hope, inclusivity, justice, and prosperity, aligning with the UFS Vision 130 strategic plan. Additionally, the exhibition added to the dialogue's impact, featuring impressive displays of cultural attire, food, and artefacts by students representing diverse African countries.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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