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UFS researchers investigate deadly fungi affecting millions in South Africa

12 June 2023 | Story André Damons | Photo Sonia Small

Prof Carolina Pohl-Albertyn — Prof Carlien Pohl-Albertyn, National Research Forum (NRF) SARChI Research Chair in Pathogenic Yeasts, leads the research team that is working on various research projects relating to fungi casing yeast.

Fungal infections affect more than one billion people each year, of which more than 150 million cases are severe and life-threatening, causing 1.7 million deaths a year. In South Africa it is estimated that diseases caused by fungal infections total more than three million cases a year. These figures are especially shocking given that prior to 1980, fungal infections were not a major health problem. The WHO has recently published a list of priority pathogens in which fungi are classified in critical, high- and medium- priority groups. Candida species are found in all three levels and Cryptococcus species in critical and medium groups,” says Prof Pohl-Albertyn.

It is for these reasons that researchers in the Department of Microbiology and Biochemistry at the University of the Free State (UFS) are working on various research projects investigating new treatment options beyond the established antifungals. Prof Carlien Pohl-Albertyn, National Research Forum (NRF) SARChI Research Chair in Pathogenic Yeasts, leads the team that is working on various research projects relating to fungi casing yeast.

Multidrug-resistant yeast

One of the yeasts being researched is Candida auris – a multidrug-resistant yeast that can cause severe infections in humans, particularly in people who are hospitalised or have weakened immune systems. C. auris was first identified in 2009 in Japan and has since been reported in over 49 countries.

According to Prof Pohl-Albertyn, C. auris is of concern because it is often resistant to multiple antifungal drugs, making it difficult to treat. In addition, it can survive on surfaces in healthcare settings, which can contribute to its spread between patients, causing outbreaks in hospitals. “Due to its multidrug resistance and potential for transmission, C. auris has been designated by the Centers for Disease Control and Prevention (CDC) as a serious global health threat and listed as the second most critical fungal pathogen in the World Health Organisation (WHO) fungal critical priority group.

“C. auris possesses virulence factors such as increased thermotolerance, high salinity tolerance, biofilm formation, and extra cellular enzyme secretion, which are the major contributing factors to its multidrug resistance profile and virulence. Even though C. auris has a variety of virulence factors that it employs against its human host to develop an infection, its virulence mechanisms remain unclear,” says Prof Pohl-Albertyn.

Therefore, several research projects investigate this pathogenic yeast. All of them started with the development of CRISP-Cas9 gene editing tools for this yeast, in order to be able to delete specific genes in this yeast to study their roles. These tools are also constantly being improved for greater efficiency by students under the supervision of Prof Koos Albertyn. Two current projects deal with the function of specific secreted enzymes in the virulence of C. auris.

Environmental yeast

Another yeast being researched, under the supervision of Prof Olihile Sebolai, is Cryptococcus neoformans, an environmental yeast found in trees and soil contaminated with bird droppings. Moreover, it can be airborne and when inhaled it lodges in the lungs (in alveoli) and can cause primary lung infection, explains Prof Pohl-Albertyn.

Cryptococcus neoformans causes AIDS-defining illnesses in people living with HIV/AIDS. To the point, it was not surprising when the WHO declared it as the first critical fungal pathogen of concern. Dissemination to other organs has been reported where it crosses the epithelium barrier by secreting proteases (a class of enzymes that break down proteins in the host) that compromise the tight junctions between the epithelial cells.

The current projects investigate the interaction between the proteases secreted by C. neoformans and co-infecting viruses, such as SARS-CoV-2 and influenza. The SARS-CoV-2 virus is activated by proteases in the host and proteases also help the influenza virus to enter and infect the host cells. Since the host proteases are similar to those secreted by C. neoformans, these projects are focused on determining if the yeast proteases can also help the viruses to cause infection. This project is also extended to study Candida albicans proteases as this is also a common co-infecting yeast in COVID-19 patients (for more detail on C. albicans).

Another project looks at the application of plants as sources for novel drugs against C. neoformans. This is important since 75-80% of African and Asian populations still rely on traditional or complementary/alternative medicines for their primary health-care needs. Coupled to this, modern medicines have become increasingly expensive and thus inaccessible to many in developing countries. Moreover, there is a shift to more “organic” and “vegan” lifestyles as well as the use of herbal medicines to prevent or manage the development of certain diseases.

Yeast contaminated water

“Considering the severity of invasive fungal infection, it is important to study the dissemination and proliferation of various pathogenic or potentially pathogenic fungal species in our surrounding environments. It is crucial to identify major vectors that aid in the spread of pathogenic yeast to prevent infections in susceptible individuals, which mainly include immunocompromised or immunosuppressed individuals.

“Candida, Cryptococcus and Rhodotorula species are commonly found in a variety of water sources with which humans are in frequent contact through daily activities like bathing, washing of clothes and cooking. This recent information further warrants the investigation into the possibility that fungal infections may occur through contact with yeast contaminated water,” concludes Prof Pohl-Albertyn.

She says it is thus important to investigate the presence and antifungal susceptibility of yeast found in water as well as to identify ways to monitor potential fungal outbreaks, possibly through wastewater surveillance. The research aims to identify potentially pathogenic yeast species as well as to quantify levels of azole, specifically fluconazole, in wastewater. In addition, the fluconazole susceptibility of these isolates will be assessed in an attempt to link azole pollution of the environment to antifungal drug resistance development.

News Archive

UFS launches history book

2007-02-02


Attending the launch of the UFS history book were, from the left: Prof Stef Coetzee, Prof Francois Retief, Prof Wynand Mouton, Mr Pieter Cox (Chairperson on Sasol) and Prof Frederick Fourie (Rector and Vice-Chancellor of the UFS). Profs Coetzee, Retief and Mouton are former rectors of the UFS.
UFS launches history book The University of the Free State (UFS) today launched its history book titled, From Grey to Gold, on the Main Campus in Bloemfontein. “The history of the UFS is one of faith, hope, struggle and determination. The book tells a fascinating story that stretches over a 100 years. It is divided into five main phases, which tells about the growth of the UFS from a poor Free State community to a mature university. Interesting stories about student days, sport, rag and hostel activities are included in each phase,” Prof Frederick Fourie, Rector and Vice-Chancellor said during the launch of the book. “One cannot know where you are going if you don’t know where you are coming from. You have a clearer idea of the issues facing an institution if you know the history. A book like this one is also an important source of reference for staff on the campus,” said Prof Fourie. The first research for the book was done from 1999-2003 by Prof Leo Barnard from the Department of History and a team of researchers. They also compiled the first manuscript. During the last three years, Prof Fourie was closely involved with the writing of the final phase and finishing off the history book project. “It was an honour to be so closely involved with the story of the UFS because now I have a better understanding of the institution, its people, its culture and its way of thinking. For any rector of a university, such an understanding of its institution is a requirement,” Prof Fourie said. The book is partly sponsored by Sasol. During the launch of the book, Mr Pieter Cox, Chairperson of Sasol said the company and the UFS have been partners for 57 years. “Both Sasol and the UFS are striving for excellence – Sasol for excellence in technology and the UFS for excellence in education,” said Mr Cox. “It was an easy decision when the UFS approached Sasol for financial support of the history book. Its a formidable piece of work, something Prof Fourie and the UFS can be proud of,” said Mr Cox. The book consists of more than 500 pages with hundreds of photos and a wide range of supplements of office-bearers, awards and achievements (including national and sporting colours). A timeline framework, putting the history of the UFS in context with the history of the Free State, South Africa and of the world, is also included. Besides the supplements, the history book also tells the story of amongst others the establishment of the UFS; the role of its founding fathers; black pioneers of transformation; the establishment and development of academic departments and faculties; student numbers; pioneers and trends in research; academic entrepreneurs; campus issues and campus politics; interesting facts and stories about student life (rag, intervarsity and cheerleaders, sport and the Springboks, hostel traditions); the admission of black students and anguish about race; language and culture; the development of the Main Campus; the Tickey and the Banana and much more. Emphasis is placed on a very high level of quality. “It is not every day that the university becomes hundred years old and the institution will be measured by the quality of the book. We cannot say the UFS is a university of excellence if the book does not reflect that,” Ms Edma Pelzer, Director: Physical Resources and Special Projects said. Ms Pelzer managed the project as part of the last mentioned part of her portfolio. The search for photographs was an important aspect of the book and it was a big task to find photographs and write captions. It took almost a year to translate and prepare the English edition and almost ten months to ensure the accuracy thereof, especially to correctly translate the typical Free State and UFS terminology and naturally to complete the English manuscript’s layout and proofreading. In the mean time the cover pages were designed and in September 2006 the manuscript went into the final print process. The Afrikaans title is: Van Sink tot Sandsteen tot Graniet. The cost of the book is R380 per copy. Those who already ordered the book will soon receive their copy. Orders can be placed by contacting Mr Dawid Kriel at UFS Marketing on 051 401 3409 or on the UFS web site at www.ufs.ac.za. The book is also available at Van Schaik Book Store on the Thakaneng Bridge, UFS Main Campus and at Fascination Books in Mimosa Mall, Bloemfontein. Media release Issued by: Lacea Loader Media Representative Tel: (051) 401-2584 Cell: 083 645 2454 E-mail: loaderl@mail.uovs.ac.za 2 February 2007

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