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23 March 2023 | Story Rulanzen Martin | Photo Stephen Collett
From left: Hanlie Grobler, Senior Officer at the CFM; Prof Koos Terblans, Head of the Physics Department; Nonkululeko Phili, Assistant Officer at the CFM; and Edward Lee, Junior Lecturer and Researcher at the CFM. Photo: Stephen Collett

The Centre for Microscopy (CFM) in the Faculty of Natural and Agricultural Sciences at the University of the Free State (UFS) unveiled a sophisticated JEOL High Resolution Transmission Electron Microscope (HRTEM) during a two-day microscopy conference on 14 and 15 March 2023. The microscope is part of a larger investment into research equipment worth R65 million. 

Speaking at the opening of the conference, Prof Corli Witthuhn, out-going Vice-Rector: Research and Internationalisation, said the microscope purchase “is a significant milestone in the university’s bid for cutting-edge research”. The HRTEM is part of a larger consignment of JEOL equipment at the UFS and, according to Dr Sarah Harper from JEOL UK, it places the UFS in a unique position.  

UFS at the forefront in using electron microscopes  

The HRTEM microscope can be utilised across disciplines and will give the UFS an advantage in uncovering new solutions and creating national and international interdisciplinary research collaborations. “The UFS is at the forefront in this field in SA and continues to push the boundaries,” Prof Witthuhn said. This move will also positively impact the training of honours, master’s, and doctoral students. 

Prof Danie Vermeulen, Dean of the Faculty of Natural and Agricultural Sciences, reiterated Prof Witthuhn’s sentiments by saying that this equipment will set the faculty apart from its competitors. “The faculty already reached the goals of Vision 130 by being proactive,” he said. In the past seven years more than R300 million worth of equipment was acquired by the faculty, but he added that to be the best is not just about the best equipment – “the data coming from using this equipment is what will make the real difference”.

Prof Koos Terblans
Prof Koos Terblans opens the conference on 14 March 2023. Photo: Stephen Collett .

Road to the JEOL HRTEM started in 2018

The process of acquiring a HRTEM microscope started in 2018 and was concluded with the purchasing of the JOEL microscopes in March 2020, a few weeks before the first COVID-19 lockdown. The purchase was made possible through the collaboration between the faculties of Natural and Agricultural Sciences and Health Sciences. Thanks to the dedication of staff members in the Centre for Microscopy and Physics, it was possible to accept delivery of the new HRTEM in June 2021. Prof Koos Terblans, Head of the Physics Department and the Centre for Microscopy, who led the entire project, said this was one of the “proudest moments in my career”.  

Installing the equipment involved various university resources, including the University Estates Department, which had to make additional structural changes to the room where the equipment is housed. This included digging two metres into the existing floor and placing the HRTEM on a 70-tonne solid concrete block, to ensure that the equipment was secure and vibration free.

Prof Terblans said now that the HRTEM from JEOL and its supporting equipment – the final piece of the R65 million research investment puzzle – is part of the faculty’s resources, it is up to the scientists and academics to utilise it for innovative research, enhance research productivity, and foster new collaborations. 

Edward Lee
Edward Lee shows the new HRTEM electron microscope to colleagues and conference attendees.Photo: Stephen Collett 

News Archive

Heart-valve studies receive international recognition
2017-07-11

 Description: Heart-valve studies  Tags: Heart-valve studies  

Prof Francis Smit, Head of the Department of
Cardiothoracic Surgery at the UFS, and Manager of the
Robert WM Frater Cardiovascular Research Centre, with
Kyle Davis, Mechanical Engineer at the centre.

Photo: Rulanzen Martin

Three heart-valve studies which have been developed at the Robert WM Frater Cardiovascular Research Centre at the School of Medicine at the University of the Free State (UFS) were recently presented in Monte Carlo at the conference of the prestigious global Heart Valve Society (HVS).

These studies are all headed by Prof Francis Smit, Head of the Department of Cardiothoracic Surgery at the UFS, and Manager of the Robert WM Frater Cardiovascular Research Centre.
Prof Smit says the HVS is a combination of the former heart-valve societies of Europe and the US. “Studies on heart-valve disease, heart-valve-related products and operations, as well as the design and development of new valves were presented. There are both clinical and development divisions.

He says the study in which the hemodynamics of their redesigned mechanical poppet valve was compared to a commercial bi-leaflet mechanical heart valve, was named as the best poster presentation in the experimental valve development and numerical flow dynamics division. The study, which was presented by Kyle Davis, mechanical engineer at the centre, competed against some of the best heart-valve research units in the world.

The redesigned valve, based on the 1960s Cape Town poppet valve, has the potential to provide a low-cost solution for mechanical heart-valve replacement. It is possible to produce the titanium ring with 3-D printers and is, together with the silicon poppet valve, extremely inexpensive compared to current mechanical valve-manufacturing processes.
The advantages of this valve over current mechanical valves is that, due to the effective and laminar flow characteristics, as well as the simple locking mechanisms, there is a reduced chance of valve thrombosis, and the need for anti-clotting drugs is therefore limited.

It was also confirmed that the new valve more than meets the published FDA (Federal Drug Agency) requirements, which determine the minimum standards of valves for human use in the US.

The redesigned valve also has a very low platelet activation impact, which is responsible for platelet thrombosis and leads to valve thrombosis or strokes. This valve is another heart-valve project by the centre, which is also in the process of evaluating a tri-leaflet polyurethane valve developed by them.


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