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29 March 2023
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Story Samkelo Fetile
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Photo Simba Matema
From left to right: Prof Jean Bernard Lekana-Douki, Director General at the CIRMF; Prof Francis Petersen, Rector and Vice-Chancellor of the UFS; and Prof Jean-Fabrice Yala, Scientific and Technical Director at the CIRMF.
The University of the Free State (UFS) recently welcomed senior members from the International Centre for Medical Research in Franceville (CIRMF), Gabon to sign a Memorandum of Understanding (MoU) between the two entities.
CIRMF is a non-profit medical research centre that was established in 1974. Its primary focus is on diagnosing infectious diseases that pose immediate problems in Gabon and the Central African sub-region. The centre is dedicated to improving public health through various initiatives, including the training of Gabonese health executives in doctoral and post-doctoral education.
“The signing of the MoU with CIRMF is a step in the right direction as the UFS continues to strengthen its footprint on the African Continent. This is seminal in driving the university’s internationalisation processes and opening an avenue to expanding research networks, especially in the African continent,” said Bonolo Makhalemele, Coordinator of strategic projects at the Office for International Affairs, UFS.
In the interest of developing broader research collaborations, the CIRMF delegation met with some UFS academics in a series of engagements, particularly in the Health Sciences Faculty and the Natural and Agricultural Sciences Faculty. “The integration of knowledge and practices that emanate from the continent provides opportunities for the co-creation of knowledge that can be shared with the rest of the world,” said Kagiso Ngake, Coordinator for Partnerships, Collaborative Degrees, and Outgoing Mobility at the Office for International Affairs, UFS.
A concrete roadmap was established to formalise the collaborations that resulted from these engagements and will commence as soon as April 2023. “We have laid a solid foundation and are on the way to a strong and rich partnership!” exclaimed Prof Jean Bernard Lekana-Douki, Director General at the CIRMF.
Prof Francis Petersen, Rector, and Vice-Chancellor of the UFS, further highlighted how the newly established partnership with the CIRMF aligns with the mandate of the UFS Vision 130 of expanding the UFS Africa research network.
UFS cardiac team leading with project
2017-05-31
Prof Peter Schultheiss of the Charité University in Berlin,
Germany, visited the Robert WM Frater Centre for
Cardiovascular Research at the UFS for a study regarding
cardiomyopathy, a significant cause of fatal heart failure
among Africans. From the left are Dr Glen Taylor,
Dr Danie Buys, Prof Makoali Makatoko,
Prof Schultheiss and Prof Francis Smit.
Photo: Rulanzen Martin
A team of cardiac doctors associated with the Robert WM Frater Cardiovascular Research Centre at the University of the Free State’s (UFS) Faculty of Health Sciences has commenced with a pioneering research project regarding idiopathic dilating cardiomyopathy.
An Afrocentric research focus
Prof Francis Smit, Head of the Department of Cardiothoracic Surgery at the UFS and Head of the Frater Centre, describes dilating cardiomyopathy as a heart muscle disease that is quite common, particularly among people of African descent. The disease weakens the heart muscle, which in turn leads to heart failure.
“To date there is no curable treatment for this condition and 50% of patients that have shown heart failure, died within a period of five years. The causes of this condition have been unknown in the majority of patients. But over the past few years major strides have been made where virus infections of the heart muscle or myocarditis have been identified as a possible underlying cause. Various genetic diseases are also linked to it,” says Prof Smit.
International collaborations ensure success
According to Prof Smit, the project is being run in conjunction with Prof Heinz-Peter Schultheiss of the Charité University and the Institute for Cardiac Diagnostics and Therapy in Berlin, Germany.
“We have been working on the project over the past 18 months and I have twice visited Prof Schultheiss in Germany. He is now visiting us in Bloemfontein. We have established a collaborative project focused on patients in central South Africa”.
Prof Schultheiss is a world leader regarding the diagnosis, pathology and treatment of dilating cardiomyopathy, says Prof Smit.
“He brings a lifetime of research experience to Bloemfontein and is internationally renowned as the father of myocardial or heart muscle biopsies.
“His pioneering work on the discipline has led to diagnostic accuracy that has induced purposeful and personalised treatment of dilating cardiomyopathy and has brought about dramatic changes in some subsets of patients’ life expectancy and their cure.”
Solving problems close to home
According to Prof Mokoali Makatoko, Head of the Department of Cardiology, there are more than 1500 new cases of heart failure identified annually at the Universitas Academic Hospital, of which approximately 30% are attributed to cardiomyopathy. “With the use of endomyocardial biopsies the team hopes to treat viruses unique to Southern Africa as well as other underlying causes of dilating cardiomyopathy.”
Prof Stephen Brown, Head of Paediatric Cardiology at the Universitas Academic Hospital, says children suffering from this disease never reach a mature age and those under his supervision will also be undergoing these tests. Various other departments at the UFS will also participate in this project. Profs Makatoko and Brown did the first four endomyocardial biopsies under the management of Prof Schultheiss during the past week. The results will be available in the coming weeks after which the project will be officially launched and patient recruitment will start in earnest.