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16 March 2023 | Story Dr Nitha Ramnath
UFS Thought Leader webinar

The University of the Free State is pleased to present its first webinar titled, The threats to South Africa’s domestic stability and security challenges, which is part of the 2023 Thought-Leader Webinar Series. As a public higher-education institution in South Africa with a responsibility to contribute to public discourse, the University of the Free State (UFS) will be presenting the webinar in collaboration with the Free State Literature Festival. The aim of the webinar series is to discuss issues facing South Africa by engaging experts at the university and in South Africa. 

First webinar presented on 4 April 2023

South Africa is facing a security risk and the state is not complying with its social contract. High crime rates driven by unemployment and poverty, collapsing infrastructure, political insecurity and tension, and an appetite for lawlessness, pose real threats to domestic stability. South Africans are cynical about state intelligence agencies, and the ability of government to lead an effective response to potential crises is questioned. What are the solutions to the threatening domestic instability and security challenges facing South Africa?

Date: Tuesday 4 April 2023
Time: 12:30-14:00
RSVP: Click here  (no later than 3 April 2023).

For further information, contact Alicia Pienaar at pienaaran1@ufs.ac.za

Some of the topics discussed by leading experts in 2022 included, among others, Crime in South Africa – who is to blame; Are our glasses half full or half empty; What needs to be done to power up South Africa; A look into the future of South Africa. 

Facilitator:

Prof Francis Petersen
Rector and Vice-Chancellor, UFS

Panellists:
Chief Executive Officer
Business Leadership South Africa

Director: Strategy and Marketing
Clarity Global Strategic Communications

Senior Professor: Centre for Gender and Africa Studies
University of the Free State

Co-Founder and Director
New South Institute

Bios of speakers:

Busisiwe Mavuso

Busisiwe Mavuso is a Chartered Certified Accountant (CCA) who qualified with the Association of Certified Chartered Accountants (ACCA – UK) and holds a master’s degree in Business Leadership, a postgraduate qualification in Management from GIBS, and a BCompt in Accounting from the University of South Africa (UNISA).  Mavuso is currently completing her PhD.

She is the Chief Executive Officer at Business Leadership South Africa (BLSA), Business Unity South Africa (BUSA), and Resultant Finance (a PIC investee company) and serves on the Human Resource Development Council (HRDC), the Advisory Committee of the Local Government Ethical Leadership Initiative (LGELI), The Alcohol Industry Advisory Council (TAIAC), the Drinks Federation of South Africa (DF-SA) Council of Members, and the Social Justice Council. Furthermore, Mavuso is a Visiting Adjunct Professor at the Wits Business School (WBS).

Mavuso is a member of the YPO (Young President’s Organisation), the IoDSA, and ACCA.

She was awarded the ‘2020 Influencer of Influencers Award’ by the Africa Brand Summit in October 2020, and was named second runner-up for ‘Businessperson of the Year’ by the Daily Maverick in 2021. In 2022, the Women in Economic Development Leadership Forum awarded her a Certificate of Acknowledgement to acknowledge the years of dedication to the field of business leadership and economic development in South Africa.

Palesa Morudu-Rosenberg 

Palesa Morudu-Rosenberg is a Director at Clarity Global, a strategic communications firm based in Cape Town and Washington DC. She is also a writer and a political commentator. She is currently writing a book on the limits of identity politics for South Africa and the United States.

Dr Ivor Chipkin

Ivor Chipkin is the Director of the New South Institute, based in Johannesburg. Before that, he was the founder and director of the Public Affairs Research Institute at the University of the Witwatersrand and the University of Cape Town for ten years. In 2017, Chipkin – with several colleagues – wrote and released the Betrayal of the Promise report, a study of state capture that had a huge political impact in South Africa. Chipkin completed his PhD at the École Normale Supérieure in France, where he also did his DEA. Chipkin was an Oppenheimer Fellow at the University of Oxford. He is the author of Do South Africans Exist? (WUP: 2007) and Shadow State: the politics of state capture with Mark Swilling (WUP: 2018). His new book, The Shattered Vessel, is due to be published in 2023.

Prof Hussein Solomon

Prof Hussein Solomon holds a DLitt et Phil (Political Science) from the University of South Africa. He is currently Senior Professor in the Centre for Gender and Africa Studies at the University of the Free State. His research interests include conflict and conflict resolution in Africa; South African foreign policy; international relations theory; religious fundamentalism and population movements within the developing world. His publications have appeared in South Africa, Nigeria, the United States, the United Kingdom, Switzerland, the Russian Federation, Greece, the Netherlands, Norway, Denmark, Egypt, Ethiopia, Israel, Lebanon, India, Bangladesh, Spain, and Japan. Hussein is widely published and some of his recent books among others include, African Security in the Anthropocene (with Jude Cocodia, Springer, 2023), Directions in International Terrorism: Theories, Trends and Trajectories (Palgrave, 2021), Terrorism in Africa: New Trends and Frontiers (with Glen Segell and Sergey Kostelyanets, Institute for African Studies, Moscow, 2021). 

Until 2022, he was Academic Head of Department in the Department of Political Studies and Governance at the University of the Free State. Hussein has vast experience -his previous appointments include Executive Director of the International Institute of Islamic Studies; Professor and Director of the Centre for International Political Studies at the University of Pretoria, Research Manager at the African Centre for the Constructive Resolution of Disputes, Senior Researcher: Institute for Security Studies, and Research Fellow: Centre for Southern African Studies at the University of the Western Cape, among others. 

 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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