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05 March 2023 | Story Kekeletso Takang and Lacea Loader | Photo UFS Photo Archive
Tate_Makgoe
Tate Makgoe, late MEC of Education in the Free State.

The management of the University of the Free State (UFS) is shocked and saddened to learn of the untimely passing of Tate Makgoe, member of the Executive Council (MEC) for Education in the Free State, who passed away on Sunday 5 March 2023 after a car accident.

MEC Makgoe was a UFS Council member as representative of the Free State Premier for two terms, from 1 November 2010 to 31 December 2018. He was also a member of the Executive Committee of Council in his second term.

“On behalf of the UFS Council, the university management, and the university community, I would like to express our heartfelt condolences to MEC Makgoe’s family, Premier Mxolisi Dukwana, and the Executive Council of the Free State, as well as the Free State education sector at large, for the loss of a great leader,” said Prof Francis Petersen, UFS Rector and Vice-Chancellor.  

MEC Makgoe had a strong relationship with the UFS, which saw him collaborating on numerous projects, including the Internet Broadcast Project from 2012 to 2022, which was aimed at supporting Grade 12 learners and teachers.

Prof Petersen acknowledged MEC Makgoe for his contributions to the university, the institution’s Council, and the province’s education sector. “We are proud to have been associated with MEC Makgoe. Not only in his capacity as MEC, but also as alumnus. He held an Honours degree in Commerce from the UFS and was registered for a PhD in Education Leadership and Policy Studies at the university at the time of his passing. In 2013, he received a Cum Laude Award during the Chancellor's Distinguished Alumni Awards ceremony,” said Prof Petersen.

Through continued collaboration and under his leadership, the Free State reclaimed its top spot in the National Senior Certificate examination results in 2019 and has maintained it to date. “This would not have been possible without the leadership of MEC Makgoe; we salute him for the significant role he played, and for his contribution to the success of the province over the past few years,” said Prof Petersen.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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