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UFS Staff member elected first female president of the Vascular Society of Southern Africa

03 October 2023 | Story André Damons | Photo André Damons

Dr Asha Malan, the Head of Vascular Surgery in the Faculty of Health Sciences at the University of the Free State (UFS), has made history by being elected as the President-elect for the Vascular Society of Southern Africa. This milestone marks the first time a woman in South Africa has attained this prestigious position in the Society’s 40-year existence.

Dr Malan, an exemplary surgeon and a trailblazer, is not only one of the seven qualified female vascular surgeons in the country but also holds the distinction of being the youngest and first female to head an academic unit in South Africa. Her election took place at the recently concluded 2023 Vascular Society of Southern Africa (VASSA) Congress, a significant event for the UFS Division of Vascular Surgery, under her leadership as the congress chairperson. The Congress was hosted at the Lord Charles Hotel in Somerset West, Cape Town, in collaboration with the World Federation of Vascular Societies (WFVS) and the European Society of Vascular Surgery (ESVS).

Reflecting on her achievement, Dr Malan remarked, “It is not only an honour to be the first woman in 40 years to lead this Society, but an honour to be elected for this role. VASSA has established a well-recognised international footprint and has invested significantly in promoting the growth of vascular surgery as a specialised surgical field in South Africa.”

She added, “Representing the Society in this capacity allows me to continue serving its members and the Southern African community, creating awareness not only about the growing burden of vascular diseases but also the advancements in the field to address these challenges.”

First gathering since 2018

The 2023 VASSA Congress marked the first gathering of Vascular Surgery specialists in South Africa since 2018, a gap caused by the pandemic. The event was attended by approximately 300 delegates, including nursing staff, radiographers, vascular technologists and other allied health professionals with a keen interest in Vascular Surgery. VASSA sponsored nursing staff, a radiographer and a vascular technologist from Universitas Academic Hospital to attend the meeting.

The high-quality, four-day programme featured talks from local and international experts covering various aspects of vascular surgery, such as aortic surgery, peripheral arterial disease, carotid pathology, dialysis access and venous disease. Notably, the academic programme saw the participation of 32 international speakers. Guest speaker, Dr Imtiaz Sooliman, the founder of the Gift of the Givers Foundation, delivered an inspiring talk during the ethics session titled “Humanitarian efforts within the Healthcare Sector – Sharing the Responsibility”.

Presentations

During the Congress, Dr Malan and several Vascular Surgeons from the Department of Surgery represented the UFS. Dr Malan shared her experiences in developing a dedicated unit for the management of complex thoraco-abdominal aneurysmal disease, a talk that garnered significant interest and applause from both local and international experts.

In her presentation, Dr Malan took the audience through her journey to several different international units to gain expertise in open thoraco-abdominal aortic surgery. She also highlighted the UFS Division of Vascular Surgery’s achievement of being the first academic Vascular Surgery unit in South Africa to perform a complex endovascular aortic aneurysm repair. In addition, Dr Sam Letsoara and Dr Wikus Mulder, Vascular Surgery Fellows in training, presented the local evolution of endovascular therapy as well as an audit of endovascular management of blunt thoracic aortic injury at Universitas Academic Hospital, respectively. Dr Sam Agbo, a registrar in the Department of Surgery, also presented his MMed research, evaluating the cost of open versus endovascular management of abdominal aortic aneurysms.

The Congress significantly contributed to the promotion of Vascular Surgical awareness and care, not only in South Africa, but across Africa and globally. It stands as a testament to the dedication and expertise of the Division of Vascular Surgery at the University of the Free State.

News Archive

UFS study on cell development in top international science journal

2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za
18 September 2008

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