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22 September 2023 | Story Supplied | Photo Supplied
Mogotsi
Milton Mogotsi, a PhD student in Medical Virology, won the Dr Lehlohonolo Mathengtheng Trophy at the Faculty of Health Sciences’ Faculty Research Forum.

Milton Mogotsi, a PhD student in Medical Virology, was awarded the Dr Lehlohonolo Mathengtheng Trophy at the recently held Faculty of Health SciencesFaculty Research Forum

Mogotsi was the recipient of the trophy for best presentation by a PhD student in the laboratory category. He is supervised by Prof Martin Nyaga, Associate Professor in the Division of Virology and Head of UFS-NGS Unit, and co-supervised by Prof Trudi O’Neill, Professor in the Department of Microbiology and Biochemistry.

The Research Forum offers staff members and postgraduate students an opportunity to present the results of their research. The Faculty Research Forum aims to provide a platform to disseminate outputs and findings of all the research conducted in the faculty, and to also provide junior researchers/postgraduate students exposure.

Results of his study 

Mogotsi presented the results of his PhD study titled “Longitudinal gut virome analysis provides insights into early gut colonisation and temporal dynamics in paediatric subjects from the Free State Province, South Africa”. His research sought to understand the longitudinal evolution of viruses colonising the gastrointestinal tract of infants during their first year of life. In this study, metagenomic next generation sequencing was performed on faecal specimens collected longitudinally from a cohort of 17 infants during their first six months. These infants were recruited from three public hospitals around Bloemfontein after consent was attained from the mothers. 

The results of this study revealed that the guts of infants are highly colonised by diverse and dynamic viral communities, formed by a richness of different viruses infecting humans, predominantly those that are associated with gastroenteritis in children. These pathogenic agents were detected as early as one day old and increasing in abundance and diversity over time, even in the absence of clinical manifestations. 

The detection of such pathogenic viruses highlights the importance of screening for intestinal pathogens at an early age to close existing gaps and enhance the effectiveness of current treatment. In addition, the detection of viruses of unknown origin in faeces of infants underscores the need to extend sampling to mothers to better understand transmission patterns of such pathogens. Importantly, interventions to improve water quality, sanitation, and hygiene at the household level would be very impactful in minimising viral transmissions to infants and reducing the high childhood morbidities and mortalities in Africa.

A great honour

“As an emerging research virologist, presenting at such forums provides me with a platform to introduce my research, but also presents the opportunity to initiate discussions with other researchers, and exchange ideas that can help improve my future scientific approaches,” says Mogotsi. 

“Being awarded the Dr Lehlohonolo Mathengtheng Trophy is such a great honour, and it came at the right time when I’m near completion of my PhD. It has really motivated me to work even harder and make sure I obtain this qualification. However, this would not have been possible without the guidance and support from my supervisor, Prof Nyaga. I want to thank him for giving me the opportunity to conduct this research project under his supervision. The continued support and encouragement from my colleagues in the UFS-Next Generation Sequencing Unit is also highly appreciated,” he concludes.

Mogotsi is finalising the write-up of his PhD thesis which he will be submitting in November 2023 for examination and is also preparing manuscripts for submission in high-impact internationally recognised peer-review journals. 

Other winners:

  • John van der Riet Medal Winners

Robyn Smith, Veronica Ntsiea, Stephen Brown, and Joanne Potterton, Department of Physiotherapy, School of Health and Rehabilitation Sciences, UFS.

Pre-operative neurodevelopmental assessment in young children undergoing cardiac surgery in central South Africa: feasibility and clinical value.

  • Muller Potgieter Medal Winners

Johannes van den Heever, Christiaan Jordaan, Angelique Lewies, Dreyer Bester, Jacqueline Goedhals, Lezelle Botes, Pascall Dohmen, and Francis Smit, Department of Cardiothoracic Surgery, School of Clinical Medicine, UFS.

Comparison of the function and structural integrity of cryopreserved pulmonary homografts versus decellularised pulmonary homografts after 180 days implantation in the juvenile ovine model.

  • Kerneels Nel Medal Winners 

Lizemari Hugo-Van Dyk, Champion Nyoni, Margaret Williams, and Benjamin Botha, School of Nursing, UFS.

Preceptor support during the COVID-19 pandemic: Recommendations for continuing development.

News Archive

Researcher takes home gold at international Famelab competition
2017-06-26

Description: Famelab competition Tags: Famelab competition

UFS researcher nabbed a top international award for
her ground-breaking metallurgical research in the UK.
Photo: Supplied

Recently, University of the Free State (UFS) Centre for Environmental Management master’s student, Tshiamo Legoale, was announced the FameLab International champion at the Cheltenham Science Festival in the United Kingdom. She is probing methods to use wheat as a gold hyper-accumulator – or, as she puts it, “grow gold from wheat”. The young researcher made South Africa proud by winning both the audience’s and the judges’ vote.

Coming back home a hero
“Winning was a surprise to me, because all 31 contestants had wonderful research. They all had really good presentations. I’m very grateful for all the support that I received from home. Social media showed me a lot of love and support. When I felt unconfident, they gave me ‘likes’ and that boosted my confidence a bit,” said Legoale about her win.

As South Africa celebrates Youth Month in June, Tshiamo represents hope for thousands of young South Africans to overcome difficult circumstances and follow careers in science.

The human impact is crucial, because Legoale’s win is not only scientific. It is also social and political. As a young female scientist in South Africa, she represented one of three African countries making it to the finals of FameLab, which has grown to one of the largest science communication competitions internationally.

With this in mind, Legoale says it may, in the end, be necessary to balance the needs of communities with the desire to increase yield. “Are we looking to make a fortune or are we looking to put food on the table?” she asks. “These are all things we consider when we conduct such research.”

World-class research from Africa
In South Africa, an estimated 17.7 million tons of gold is wasted. “All this gold was mined out previously, but tiny amounts remain in the dumps,” Legoale explains.

Her research focuses on the uses of wheat as a gold hyper-accumulator, which essentially means wheat plants are used to harvest gold from mine dumps. Simply put, the wheat is planted in the dumps, where enzymes found in the roots react with the gold and the plant absorbs it. The gold is then absorbed by every part of the plant, except the seeds, which means the next harvest can be used for food if need be.

“South Africa's world-champion young scientist, Tshiamo, represents all that is good about this country – brilliant, bright, and set for a fine future. I'm so proud that British Council SA, together with our partners SAASTA and Jive Media Africa, can help her along the way. Huge congratulations to her from all of us – it is a big win for Africa on the world stage,” said Colm McGivern, British Council South Africa Country Director.

The research represents a win on multiple levels. First, there are the obvious potential socio-economic benefits: food production, job creation, and phytomining is more economical than other contemporary mining methods.

Then there is safety. It is a more environmentally friendly practice than methods like heap leaching, carbon-in-leach or carbon-in-pulp. It is also safer for miners themselves, who will not be exposed to dangerous chemicals like mercury, which has been responsible for a great deal of toxicity in mine dumps. And it is safer for those living in the surrounds.

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