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19 April 2024 | Story André Damons | Photo Supplied
Dr Milton Mogotsi
Dr Milton Mogotsi graduated on Thursday with the degree Doctor of Philosophy with specialisation in Virology during the Faculty of Health Sciences at the University of the Free State (UFS) autumn graduation ceremonies.

A pilot study for his master’s degree not only ignited Dr Milton Mogotsi’s passion but he was also inspired by the fact that this was a newly emerging field of research in the discipline of virology at the time. This eventually led to him pursuing a PhD and ing on his research.

Dr Mogotsi graduated on Thursday (18 April) with the degree Doctor of Philosophy with specialisation in Virology during the Faculty of Health Sciences at the University of the Free State (UFS) autumn graduation ceremonies. Prof Martin Nyaga, Head of the Next Generation Sequencing Unit (UFS-NGS) and an associate professor in the Division of Virology, was his promotor and Prof Trudi O’Neill from the Department of Microbiology and Biochemistry his co-promotor.

“It feels great! It was exhausting and overwhelming at times, but that light at the end of the tunnel will start to be brighter. I feel so proud of myself and very free. Nothing beats that liberating feeling that I have successfully completed a doctoral degree and now a new chapter of my life begins. I believe this post-PhD period is an excellent time for reflecting on my attributes and revising my CV, and with a PhD degree under my belt, I look forward to an abundance of opportunities that will soon open up,” says Dr Mogotsi after graduating.

Research

According to him, he was first introduced into this research concept when he was doing his master’s degree in microbiology. “Although it was more of a pilot study aiming to assess the feasibility of conducting this type of research on a larger scale, we made some interesting findings which we published in an international journal.

“I obtained my degree with distinction, receiving an award for Best Master’s Dissertation in Microbiology. The findings of this research really ignited my passion, and I was also inspired by the fact that this was a newly emerging field of research in the discipline of virology at the time, and of course in my master’s research there were some gaps and limitations which needed to be addressed. I then took a decision to pursue a PhD and expand on that research, and working with new-born babies is always enjoyable,” says Dr Mogotsi. 

With his thesis titled “Longitudinal characterisation of the enteric virome of infants from the Free State, South Africa, using viral metagenomics”, Dr Mogotsi’s research aimed to characterise the total assemblage of all viruses that colonise the gastrointestinal tract of newborns, often referred to as the gut virome, using metagenomics.

“We know that the human gut undergoes some changes as the new-born baby becomes exposed to the numerous microorganisms, such as viruses, from the immediate environment. This once-in-a-lifetime occurrence can have life-long effects on the health and disease state of humans. Viral intestinal infections are among the leading causes of childhood hospitalisations and deaths, especially in Africa, and infants are at a greater risk of suffering severe illnesses due to their immature immune system,” he explains.

According to him, previous research had focused more on the investigating the population of bacteria present in the gut of new-borns, therefore, there’s a huge knowledge gap about viruses colonising this part of the human body. In South Africa, more attention has been on assessing the effectiveness of currently available vaccines and surveillance of specific disease-causing viruses such as rotavirus.

The research he was conducting, he continues, therefore, sought to characterise all intestinal viruses in healthy new-borns individuals, their source of origin, the changes in diversity and composition occurring over time, as well as their potential implications on the health of infants. “The findings of my study have provided more insights into what is known or new viruses are colonising the infants’ gut, as well as their evolution over time”, he adds.

PhD journey

Even though he had to put his PhD on hold for a year due to COVID-19, but with the resilience, persistence, and his ability to clear the roadblocks that were in his way, he managed to complete it. He also credits his supportive mentors and a community of colleagues and friends for their unwavering support throughout his academic journey.

“After a year-long delay, I was able to go ahead with the project and everything went well from sample collection and sample processing in the lab. The challenging part was analysing and interpreting the data as this involved advanced bioinformatics, but in the end, I was able to find solutions and make sense out of the results I got. The study was a great success with two publications in peer-reviewed international journals emanating from this study.

“Furthermore, I had an opportunity to present my research in local and international conferences. I have been to Ghana, Nigeria and Indonesia. Locally, I presented in a conference in Johannesburg and in Cape Town. More exciting was participating in the Three Minute Thesis (3MT) competition in which I emerged victorious, winning the National 3MT competition. The other award I received was from the Faculty of Health Sciences Research Forum, winning the Dr Lehlohonolo Mathengtheng Trophy for best PhD presentation”, says Dr Mogotsi.

Motivation

Dr Mogotsi says the fact that he comes from the township and received his secondary education from a township school always kept him motivated. He is well aware that there are many who look up to him, who are also inspired by what he has achieved.

“More importantly, my supervisor, Prof Nyaga, was very supportive and he is very active in his research field with genuine interest in student projects, while making time to provide adequate supervision and mentorship. His high standards of ensuring that students graduate with a strong publication record is commendable.”

As a coordinator of wet lab activities at the UFS-NGS Unit, Dr Mogotsi is currently involved in several projects as the unit is a World Health Organisation Collaborating Center for Vaccine Preventable Diseases and Pathogen Genomics. They are doing collaborative projects with several partners across the continent on the genomic surveillance of enteric viruses such as rotavirus, norovirus, sapovirus, astrovirus and adenoviruses. 

News Archive

Free State Receives R7 Million Grant from the Mellon Foundation for Arts Innovation
2015-11-30


Man in the Green Blanket, Lesiba Mabitsela.
Photo: Karla Benade

Bloemfontein will experience a flood of new, experimental art over the next four years as a result of R7 million that has been received to develop experimental art projects in central South Africa. The Andrew W. Mellon Foundation recently awarded the grant to the University of the Free State (UFS) for the Programme for Innovation in Artform Development (PIAD). Initiated jointly by the UFS and the Vrystaat Arts Festival in 2014, PIAD was established as a programme to promote the exploration of the arts to advance interdisciplinary research and to impact on human development.

The Andrew W. Mellon Foundation is a New York-based, non-profit organisation which endeavours to strengthen, promote, and, where necessary, defend the contributions of the humanities and the arts to human flourishing, and to the well-being of diverse and democratic societies.

“The Innovation in Artform Development initiative will provide an important contribution to the ways in which the university hopes to broaden and deepen research and dialogue about the humanities in South African society. Using the arts as a vehicle to engage communities around issues of social significance, makes for an exciting endeavour, and we are happy to have Mellon’s financial and partnership investment in this initiative,” said Prof Jonathan Jansen, Vice-Chancellor of the UFS.

“This substantial support from the Foundation will play a pivotal role in facilitating collaborations with national and international artists to explore new, innovative modes of artistic practice and creative production in South Africa,” said Angela de Jesus, UFS Art Curator and Co-Director of PIAD.

“A series of First Nations projects, arts/science research and artist residencies, arts laboratories for creative practitioners, the production of exciting new work for Bloemfontein, and critical debates/forums is expected over the next few years,” she added.

PIAD focuses on supporting cross-cultural, experimental art programmes that can assist South African society creatively. For this process, PIAD is engaging the skills and expertise of South Africa artists in collaboration with several international partners, who are recognised as global leaders in this field, to develop a mutually- beneficial programme of engagement.  

Innovation, technology, and new forms of art will be explored and international collaborations that have the potential to attract benefits for the creative industries in Bloemfontein and beyond will be introduced.

“The artistic landscape of the Free State - in fact the whole South Africa - will be forever changed because of this extraordinarily generous grant. Rarely does a regional community get a chance to lead innovation on a national scale, and also impact on experimental art internationally. We are in for an incredible artistic journey,” said Dr Ricardo Peach, Director of the Vrystaat Arts Festival and Co-Director of PIAD.

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