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19 April 2024 | Story André Damons | Photo Supplied
Dr Milton Mogotsi
Dr Milton Mogotsi graduated on Thursday with the degree Doctor of Philosophy with specialisation in Virology during the Faculty of Health Sciences at the University of the Free State (UFS) autumn graduation ceremonies.

A pilot study for his master’s degree not only ignited Dr Milton Mogotsi’s passion but he was also inspired by the fact that this was a newly emerging field of research in the discipline of virology at the time. This eventually led to him pursuing a PhD and ing on his research.

Dr Mogotsi graduated on Thursday (18 April) with the degree Doctor of Philosophy with specialisation in Virology during the Faculty of Health Sciences at the University of the Free State (UFS) autumn graduation ceremonies. Prof Martin Nyaga, Head of the Next Generation Sequencing Unit (UFS-NGS) and an associate professor in the Division of Virology, was his promotor and Prof Trudi O’Neill from the Department of Microbiology and Biochemistry his co-promotor.

“It feels great! It was exhausting and overwhelming at times, but that light at the end of the tunnel will start to be brighter. I feel so proud of myself and very free. Nothing beats that liberating feeling that I have successfully completed a doctoral degree and now a new chapter of my life begins. I believe this post-PhD period is an excellent time for reflecting on my attributes and revising my CV, and with a PhD degree under my belt, I look forward to an abundance of opportunities that will soon open up,” says Dr Mogotsi after graduating.

Research

According to him, he was first introduced into this research concept when he was doing his master’s degree in microbiology. “Although it was more of a pilot study aiming to assess the feasibility of conducting this type of research on a larger scale, we made some interesting findings which we published in an international journal.

“I obtained my degree with distinction, receiving an award for Best Master’s Dissertation in Microbiology. The findings of this research really ignited my passion, and I was also inspired by the fact that this was a newly emerging field of research in the discipline of virology at the time, and of course in my master’s research there were some gaps and limitations which needed to be addressed. I then took a decision to pursue a PhD and expand on that research, and working with new-born babies is always enjoyable,” says Dr Mogotsi. 

With his thesis titled “Longitudinal characterisation of the enteric virome of infants from the Free State, South Africa, using viral metagenomics”, Dr Mogotsi’s research aimed to characterise the total assemblage of all viruses that colonise the gastrointestinal tract of newborns, often referred to as the gut virome, using metagenomics.

“We know that the human gut undergoes some changes as the new-born baby becomes exposed to the numerous microorganisms, such as viruses, from the immediate environment. This once-in-a-lifetime occurrence can have life-long effects on the health and disease state of humans. Viral intestinal infections are among the leading causes of childhood hospitalisations and deaths, especially in Africa, and infants are at a greater risk of suffering severe illnesses due to their immature immune system,” he explains.

According to him, previous research had focused more on the investigating the population of bacteria present in the gut of new-borns, therefore, there’s a huge knowledge gap about viruses colonising this part of the human body. In South Africa, more attention has been on assessing the effectiveness of currently available vaccines and surveillance of specific disease-causing viruses such as rotavirus.

The research he was conducting, he continues, therefore, sought to characterise all intestinal viruses in healthy new-borns individuals, their source of origin, the changes in diversity and composition occurring over time, as well as their potential implications on the health of infants. “The findings of my study have provided more insights into what is known or new viruses are colonising the infants’ gut, as well as their evolution over time”, he adds.

PhD journey

Even though he had to put his PhD on hold for a year due to COVID-19, but with the resilience, persistence, and his ability to clear the roadblocks that were in his way, he managed to complete it. He also credits his supportive mentors and a community of colleagues and friends for their unwavering support throughout his academic journey.

“After a year-long delay, I was able to go ahead with the project and everything went well from sample collection and sample processing in the lab. The challenging part was analysing and interpreting the data as this involved advanced bioinformatics, but in the end, I was able to find solutions and make sense out of the results I got. The study was a great success with two publications in peer-reviewed international journals emanating from this study.

“Furthermore, I had an opportunity to present my research in local and international conferences. I have been to Ghana, Nigeria and Indonesia. Locally, I presented in a conference in Johannesburg and in Cape Town. More exciting was participating in the Three Minute Thesis (3MT) competition in which I emerged victorious, winning the National 3MT competition. The other award I received was from the Faculty of Health Sciences Research Forum, winning the Dr Lehlohonolo Mathengtheng Trophy for best PhD presentation”, says Dr Mogotsi.

Motivation

Dr Mogotsi says the fact that he comes from the township and received his secondary education from a township school always kept him motivated. He is well aware that there are many who look up to him, who are also inspired by what he has achieved.

“More importantly, my supervisor, Prof Nyaga, was very supportive and he is very active in his research field with genuine interest in student projects, while making time to provide adequate supervision and mentorship. His high standards of ensuring that students graduate with a strong publication record is commendable.”

As a coordinator of wet lab activities at the UFS-NGS Unit, Dr Mogotsi is currently involved in several projects as the unit is a World Health Organisation Collaborating Center for Vaccine Preventable Diseases and Pathogen Genomics. They are doing collaborative projects with several partners across the continent on the genomic surveillance of enteric viruses such as rotavirus, norovirus, sapovirus, astrovirus and adenoviruses. 

News Archive

Statement by the senior leadership of the University of the Free State
2016-02-29

Statement by the senior leadership of the University of the Free State regarding the situation on the Bloemfontein Campus 

All academic and administrative activities on the Bloemfontein and South Campuses of the University of the Free State (UFS) resume on Monday 29 February 2016.

In light of the recent incidents on the Bloemfontein Campus, the university leadership would like to address the understandable concerns of students, staff and the general public. The university obviously respects the rights of individuals to freedom of speech and expression, but notes that these rights are subject to reasonable limitation, and cannot extend to justifying criminal acts.

The Bloemfontein Campus is secure and security measures have been doubled up to ensure the safety of students, staff and public property. The court interdict is in place and will be enacted if required. Unlawful disruptions, including those involving criminal conduct, will not be tolerated.

The university strongly condemns the unlawful and unacceptable conduct by students, protesting outsourced workers, and visitors to its campus during the past week, and in particular the assault on protestors at Xerox Shimla Park on Monday 22 February 2016 during a Varsity Cup rugby match between the FNB Shimlas and FNB Madibaz. The university has started a comprehensive and independent investigation into criminal activities on this campus before, during and after the Xerox Shimla Park events.

The university regrets the destruction of public property and the intimidation of staff and students which led to the shutdown of academic and administrative activities on the Bloemfontein Campus. Extensive investigations are underway to identify the perpetrators who took part in all incidents of disruption and criminal conduct, and urgent steps will be taken against such individuals or organisations in due course.

The university leadership remains deeply concerned about a dangerous and damaging allegation that a lecturer was identified on a widely circulated photograph while assaulting a protestor at the Varsity Cup rugby match on Monday 22 February 2016. The university diligently investigated this allegation and found it to be false; the individual is NOT a member of the UFS staff. A suspect was however identified and evidence handed over to the South African Police Services (SAPS) for urgent action.

It has further come to the attention of the university management that a number of individuals and organisations continue to make blatantly false and defamatory statements on social media platforms with the intention of inciting criminal conduct, threatening individuals, and spreading fear within the university community in order to unsettle the campus. Investigations are at an advanced stage to prosecute individuals and groups involved in such criminal conduct in the social media; both those who post these statements and those who repost or retweet them, are liable under the law.

Should you wish to confirm whether there is any truth attached to a circulated rumour or allegation, please call +27(0)51 401 2911, +27(0)51 401 2634 or send an email to news@ufs.ac.za. Legal steps will be taken against individuals and organisations that persist in circulating such misleading and damaging statements.
    
The UFS urges all individuals who are in possession of evidence or knowledge of any crimes that have been committed on the Bloemfontein Campus in the past week, to come forward with such evidence and information and to call the numbers indicated above or to send an email to news@ufs.ac.za. Any individuals who are in possession of video footage and photographs of the incidents at Xerox Shimla Park, the Equitas Building (formerly known as the CR Swart Building), Thakaneng Bridge, various residences, the Main Building and the grounds in front of the building, are requested to provide such evidence in order to assist with the identification of those involved in criminal acts.

The university leadership remains committed to its duty to act in the best interests of its students and staff and calls on its community and the public to act peacefully at all times and respect the rights of others.

Issued by: Lacea Loader
(Director: Communication and Brand Management)
Email: news@ufs.ac.za

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