Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
01 April 2024 | Story Lacea Loader | Photo Sonia Small
Prof John Klaasen, newly appointed Dean: Theology and Religion at the UFS
Prof John Klaasen, newly appointed Dean: Theology and Religion at the UFS.

The University of the Free State (UFS) has appointed Prof John Klaasen as Dean: Faculty of Theology and Religion from 1 April 2024. 

Prof Klaasen is Professor of Theology and has served two terms as Head of the Department of Religion and Theology at the University of the Western Cape. He also served as Professor in the Kjell Nordstokke Chair in Community Development at VID Specialized University in Norway and is Adjunct Professor at VID Specialized University. 

“With his vast experience and involvement in research projects – nationally as well as internationally – Prof Klaasen will make a significant contribution to the Faculty of Theology and Religion and the university in general. This will also be valuable in support of the university’s Vision 130, which is an expression of our strategic intent to position the institution towards 2034 when the UFS will be 130 years old,” says Prof Francis Petersen, Vice-Chancellor and Principal of the UFS.

As a practical theologian, the intersection between praxis and theory has occupied Prof Klaasen’s research for the past decade. He has researched and published extensively within theology, community development, and narrative. Aspects such as narrative, embedded knowledge, participation, reconciliation, and the non-rational tradition of knowledge are some of the areas that occupy his research outputs.

He is involved in numerous international research projects, which include a COST project with 17 European institutions, a project on reconciliation processes with institutions in Canada and Nordic countries, an international initiative on community development with various institutions in Europe, and a NORPART initiative with Norway and Malawi.

Community engaged scholarship forms a central part of his research and work at the intersection of religion and social justice. Prof Klaasen is involved in various community development projects, including homes for the aged, lay training, water issues, and lay theological education.

His teaching is situated within a socially just pedagogy, which puts the students at the centre of knowledge production. This innovative way of knowledge production intersects students, teachers, and the lecture room within a dynamic space of contextualisation.

“I am grateful for the opportunity to join such a prestigious institution and will endeavour to contribute to Vision 130 through commitment, innovation, trust, and ethical leadership – which represents the university’s commitment to be recognised by our peers and society as a top-tier university in South Africa, ranked among the best in the world,” says Prof Klaasen.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept