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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS Council appoints agency to assist with its residence integration policy

2008-06-06

The Council of the University of the Free State (UFS) has appointed the Cape Town based iGubu Leadership Agency to assist with its residence integration policy.

“The agency will assist management in understanding and identifying the current obstacles related to the implementation of the residence integration policy, draw up proposals to enhance and successfully implement this integration policy, and implement these proposals to ensure successful integration within the 21 residences on the Main Campus in Bloemfontein,” says Prof. Teuns Verschoor, Acting Rector of the UFS.

The agency was appointed after an intensive advertising, screening and interviewing process was conducted by the university’s management. A recommendation on the successful candidate was subsequently made to the Council and the iGubu Leadership Agency was informed of its appointment this past week,” says Prof. Verschoor.

“Some of the projects that we have been involved in include the development and management of student leadership at among others the universities of Stellenbosch and Cape Town as well as the Huguenot College, and leadership initiatives such as the Beeld Youth Summit and last year’s Brightest Young Minds conference,” says Mr Rudi Buys, Chief Executive Officer. He will be working with Mr Yeki Mosomothane, Strategy Manager of the agency and a diverse team of facilitators.

Their main focus will be on investigating the trust relationships between stakeholders, establishing healthy relationships between students and the development of the skills of student leaders to establish conversations on values and meaningful change in residences and the student community.

“In the first phase of the project we will be conducting research and talk to students and other role players regarding ways of building unity on campus. After that the kind of programmes that may be implemented to further integration in residences will be determined together with stakeholders and the most suitable ones will be implemented. We will emphasise ownership and participation of processes by students and other stakeholders to ensure sustainability,” says Mr Buys.

The contract is for two and a half years and the agency must regularly report to Council via management on its progress. “We see this appointment as an investment in the integration of our residences and look forward to the interventions iGubu Leadership Agency can bring to the table,” says Prof. Verschoor.

The agency specialises in mentoring individuals and teams and in facilitating the participation of communities in transformation and reconciliation initiatives in specifically an African context, and does so from a leadership development perspective. The agency has extensive experience in facilitating programmes for diversity and integration.

iGubu Leadership Agency’s appointment goes hand in hand with the appointment of other agencies who will support management and make recommendations on how to accelerate transformation and position the UFS as an engaged and responsive university.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za
6 June 2008

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