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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

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Qwaqwa Campus honours academic excellence
2017-05-18

Description: QQ autumn Graduation 2017 Tags: QQ autumn Graduation 2017

Photo: Ian van Straaten

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Qwaqwa Campus kicked off the 2017 graduations season of the University of the Free State in style when over 550 degrees and certificates were conferred in three sessions on 12 and 13 May 2017. These included five PhDs from the Faculty of Natural and Agricultural Sciences.

In his maiden speech delivered during the two ceremonies on Friday 12 May 2017, the newly-appointed Vice-Chancellor and Rector, Prof Francis Petersen, emphasised the interconnectedness of graduates with other stakeholders in their communities.

“Never forget the role played by other people who sacrificed a lot for you to be here today. Recognise the extra mile that someone was willing to go for you to graduate,” he said to an enthusiastic audience that included Grade 12 learners from neighbouring schools. 

Prof Petersen also reminded the graduates that not everybody had an opportunity to enter, enrol, and eventually graduate at a university. “You are part of the privileged few, and I am confident that the UFS has given you an equal opportunity to reach your full potential. You have had years of exposure to ideas and experiences on diversity. You now have the opportunity to show the world and to use what you have learnt beyond a classroom,” he added.

“Go out there and open doors for others as much as they were opened for you. I implore you to carry over your experiences of diversity and use them to build a better world. Go out there and build a better world, not only for yourself but for everyone in need. Expand your influence, reach out, and be accountable,” he said.

“South Africa needs your skills,
innovation, knowledge, expertise,
and creativity.”

Make your own unique contribution
The session held on Saturday 13 May 2017 saw the Principal of Motheo TVET College and Qwaqwa Campus alumnus, Dipiloane Phutsisi, having a heart to heart with the graduates from the Faculty of Education.

“Our contribution to the world as graduates will not be measured by the wealth we accumulate or the accolades we receive, but rather by the way in which we share our unique gifts with the world. And the only place to find those gifts is to look within yourself. As the class of 2017, make your own unique contribution,” she said.

“Your graduation takes place at a particularly challenging time in the history of our democracy. It happens at a time when our nation is engulfed by racial polarisation, anger, confusion about what democracy and freedom mean to us, and at a time when the pillars of morality are tested.”

“As you graduate, I wish to remind you that our country needs you more than ever before. South Africa needs your skills, innovation, knowledge, expertise, and creativity,” she said.

Three members of the current SRC were also among the graduates. They are the President, Njabulo Mwali (BSc Information Technology), Sports Affairs Officer, Ntokozo Thango (BA Sociology), and Student Development and Environmental Affairs Officer, Ntokozo Masiteng (BA Sociology).

 

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