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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Louzanne breaks own world record in Switzerland
2017-06-09

Description: Louzanne breaks own world record  Tags: Louzanne breaks own world record

Rufus Botha (left), coach of the athlete Louzanne Coetzee,
went overseas with Coetzee and her guide,
Khothatso Mokone, for a race for the first time.
Coetzee improved her T11 5 000 m world record with more
than 20 seconds in Switzerland.
Photo: Johan Roux

She fought against illness, had to get the green light from medical personnel shortly before her main race, and was very nervous. However, on 5 June 2017, the blind athlete Louzanne Coetzee managed to improve the T11 5 000 m world record with more than 20 seconds.

The Kovsie star’s time of 18:14.27 at the ParAthletics Grand Prix in Nottwil, Switzerland, was approximately 23 seconds faster than her previous world record (18:37.23). In addition, Coetzee, who works at the Institute for Reconciliation and Social Justice at the University of the Free State, also improved the South African T11 800 m record to 2:30.18 on 2 June 2017, and her 4:59.54 on 3 June 2017 in the T11 1 500 m was almost another national record.

Carried by UFS and other support
“One could never be ungrateful when running close to your personal best,” Coetzee said. “Fortunately, with God’s blessing, the support of everybody at home, support from the university, as well as my mom and them, it really was a very blessed and successful event.”

According to her coach, Rufus Botha, Coetzee was not feeling well before the event and had to get medical clearance before the 5 000 m. He told her not to run too hard, even though their goal was 18:20. “She ran an incredible final 600 m, which brought the time down to 18:14,” he said. “It was amazing to watch.”

Botha’s knowledge valuable abroad
He enjoyed going overseas with Coetzee and her guide, Khothatso Mokone, for the first time. “His (Botha’s) experience, knowledge, support, and coaching was extremely valuable,” Coetzee said. “It will definitely help me in future: how to approach things, and everything he shared with us.”

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