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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

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Graduates should make a difference as leaders and be agents of change
2017-06-22

Description: Mid-year graduation read more 22 June 2017 Tags: Mid-year graduation read more 22 June 2017

More than 5 000 degrees will be conferred over six days
and eleven ceremonies at the UFS mid-year graduation
ceremonies.
Photo: Johan Roux

Livestream of Graduation Ceremonies

“Make the choice to make a difference as the leaders of the future.” These words of Dr Susan Vosloo, Cardiothoracic Surgeon and member of the University of the Free State (UFS) Council, echoed the call to graduates on the first three days of the UFS mid-year graduation ceremonies. The ceremonies are taking place in the Callie Human Centre on the Bloemfontein Campus from 19 to 26 June 2017.

Dr Vosloo, also an alumna of the UFS, was one of six guest speakers at the biggest set of graduation ceremonies in the university’s history. A spirit of excitement is part of the festivities, as a total of 5 258 degrees will be conferred over six days in eleven ceremonies. The graduation week will conclude on 26 June 2017, when 460 master’s and doctoral degrees will be conferred – 72 of these are doctoral degrees.

Stand up and be counted
Dr Vosloo urged the graduands at the afternoon session on 19 June 2017 to stand up and be counted. “What we need are leaders who treasure integrity, dignity, accountability, transparency, and who will focus on the common challenges which we all face today.”

Dr Khotso Mokhele, UFS Chancellor, also encouraged the graduates to be agents of change who shouldn’t conform to the current system. “Decide that it is your country and that you will decide what it should be. Then it will not be the corrupt experiment which the current government turned it into. We wish you well. Go and be the agents of transformation.”

Ambassadors of the UFS
Prof Francis Petersen, UFS Rector and Vice-Chancellor, asked the graduates to make a contribution: “Be excellent ambassadors of the UFS, and make the UFS, your families, and our country proud by your strong, innovative, ethical, and excellent contributions.” He was the guest speaker during the morning and afternoon sessions on 20 June 2017.

He also said that they should never forget the supporting role others played in their success, whatever form it took.

Do it for those who fought for SA
Justice Connie Mocumie, Judge of Appeal at the Supreme Court of Appeal, encouraged the graduates to go out and contribute to the development of the country. She was the guest speaker at the morning and afternoon ceremonies on 21 June 2017.

“It is important for you to continue being experts in your area of expertise,” she said.

“Today is the beginning of better days to come. Do it for the legacy of those who fought for our country in pursuit of a better South Africa.”

Dipiloane Phutsisi, Principal and Chief Executive Officer of the Motheo TVET College in the Free State, said everyone is destined for greatness. “In the words of Dr Martin Luther King: Everyone has the power for greatness, not for fame but greatness, because greatness is determined by service.” She was the guest speaker at the morning session on 19 June 2017.

Click here to see a list of Deans’ and Senate medals awarded.

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