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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Van Niekerk shines in Ostrava and breaks 300 m world record

2017-06-29

Description: Van Niekerk shines in Ostrava Tags: Van Niekerk shines in Ostrava

Wayde van Niekerk is in great form leading up to the
World Championships in London in August.
Photo: Khothatso Mokone

Usain Bolt believes Wayde van Niekerk could well be his successor. Bolt, who has won eight Olympic and 11 world gold medals in his career, doesn’t doubt that the Kovsie athlete could take over the reins as an athletic superstar.

This after Van Niekerk broke another world record by Michael Johnson – 30.85 seconds in the 300 m which Johnson set in Pretoria in 2000 – at the IAAF Golden Spike meeting in Ostrava, Czech Republic, on 28 June 2017. He took the honours in the 300 m in a time of 30.81 seconds. In 2016, Van Niekerk also improved on Johnson’s 400 m world record (43.18 s) with a time of 43.03 s at the Rio Olympics.

Unique honour over four distances
Because the 300 m event is not run very often, the record will be regarded as the world’s best by the IAAF. According to the IAAF, the 24-year-old Van Niekerk is now also the first man to run a sub-10 for the 100 m, sub-20 for 200 m, sub-31 for 300 m, and sub-44 for 400 m.

The legendary Bolt, who is in his final season, admitted that Van Niekerk could take over from him. “I think he really wants to be a sprinter, because he's set a personal best in the 100 m this year,” he said to AFP.

“He's shown that he's ready for the challenge. He's really down to earth, he's really humble, he's a great person. He listens and wants to be good, and if he continues like this he'll take over track and field."

Great run prior to Czech Republic
The 300 m world record follows after Van Niekerk also ran a personal best time of 9.94 in the 100 m in Velenje, Slovenia, on 20 June 2017. The 400 m world record-holder also became the South African record-holder in the 200 m again when ran a 19.84 in the 200 m at the Racers Grand Prix in Kingston, Jamaica, on 11 June 2017.

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