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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Prof Moffett’s third book provides comprehensive guide to Basotho medicinal plants

2017-07-26

Prof Rodney Moffett’s three books documenting Basotho
plants, animals, and the history of the Free State and Lesotho.
Photo: Thabo Kessah

Prof Rodney Moffett has recently published his third book, Basotho Medicinal Plants – Meriana ya Dimela Tsa Basotho. This latest offering deals only with medicinal uses and is based on the data from his first book, Sesotho Plant and Animal Names and Plants Used by the Basotho.

“The latest book came about after a Sesotho language advisor in the Free State Department of Education suggested that there was a need for the medicinal uses of plants by the Basotho to be documented in the vernacular. In a situation where there is an almost total lack of scientific literature in the vernacular, the greatest value of this book therefore, is that it provides a comprehensive guide to the medicinal uses of plants in Sesotho,” said Prof Moffett, Honorary Research Associate in the Department of Plant Sciences on the Qwaqwa Campus.

Book lists names of plants in Sesotho
“It comprises two parts. Part one lists the medicinal categories and plants used, and part two lists the medicinal uses arranged according to the Sesotho names of the plants. It is easy to read, as the information is presented alphabetically with the Sesotho name first, followed by the scientific name and usage thereof. Because a plant often has more than one Sesotho name, the scientific name is included to identify it.”

Prof Chris Nhlapo, Deputy Vice-Chancellor of the Cape Peninsula University of Technology, and Prof Ntsamaeeng Moteetee from the University of Johannesburg are impressed with the book, respectively saying that it assists in documenting the deep indigenous knowledge of the “proud tradition of the Basotho Nation” and it is “an important contribution to the documentation of medicinal plant uses”.

The title of Prof Moffet’s second book was A Biographical Dictionary of Contributors to the Natural History of the Free State and Lesotho.

Prof Moffett was honoured with a Lifetime Researcher Award during the Academic and Research Awards on the Qwaqwa Campus in November.

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