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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

#Women’sMonth: A career in Sign Language interpreting proves to be full of rewards for Natasha Parkins-Maliko
2017-08-03

 Description: Natasha Parkins-Maliko new Tags: Natasha Parkins-Maliko new 

Natasha Parkins-Maliko. She
was recently awarded the Pansalb
Multilingual Award in the category:
Translation and Interpreting 2016/2017,
as recognition for her achievements
in a sixteen-year career.
Photo: Supplied

Natasha Parkins-Maliko is an alumna of the University of the Free State who graduated with a master’s in Linguistics. She is a well-rounded interpreter with a language combination of South African Sign Language-English-Afrikaans. She continued her studies and achieved an international master’s in Sign Language interpreting at the Humak University of Applied Sciences in Finland.  Natasha was recently presented with the Pansalb Multilingual Award in the category: Translation and Interpreting 2016/2017, as recognition for her achievements in a sixteen-year career.

“Winning the Pansalb Translation and Interpreting Award for 2016/2017, was for me as Kovsie a pat on the back in the true sense of the word.  The university is where I started my journey in South African Sign Language interpreting, and from then on, I never looked back,” she said.

Her interpreting career has provided many challenges, and was accompanied by great achievements along the way.

A career of fulfilment in Sign Language

“The foundation of my success was laid by my lecturers and mentors, such as Dr Philemon Akach and Emily Matabane, where I trained in the Department of South African Sign Language (SASL) at the university.”

“My determination and success is grounded in the motto, ‘Inspiring Excellence, Transforming Lives’ – a continued journey in excellence gives a renewed sense of pride for all language practitioners in South Africa,” she said.

Natasha went on to work in the deaf community for most of her career. She started as a grassroots interpreter, and is now a professional interpreter registered with SATI (South African Translators Institute). She is also a Sign Language television interpreter on SABC for content such as SABC 3 news bulletins, the budget speech, opening of Parliament, Youth Day broadcasts, January 8th statement broadcasts, MPC Reserve Bank speeches, and many more. Natasha is not only concerned with growing her career – despite her mover and shaker persona, she still takes time to volunteer her services for deaf people who do not have the financial ability to pay for interpreting.

“Winning the Pansalb Translation and
Interpreting Award for 2016/2017, was
for me as Kovsie a pat on the back in
the true sense of the word.”

The journey to excellence never stops
Over and above lecturing in Interpreting and Translation at Wits University, Natasha is still in pursuit of excellence. She is a PhD candidate in the SASL Interpreting programme at Wits University, the first of its kind in the country, and is pursuing an AIIC (International Association of Conference Interpreters) accreditation. Her aim is to put South African Sign Language interpretation on the global map.

As a role model and icon in her field, Natasha is the chairperson of the National Association of South African Sign Language Interpreters (NASASLI), the regional coordinator for the African Federation of Sign Language Interpreters (AFSLI), and the Africa regional representative on the board of the World Association of Sign Language Interpreters (WASLI).  The award presented to her is no doubt a fitting accolade and something all UFS alumni takes pride in.

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