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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Quantity Surveying and Construction Management department aspires to excellence
2017-08-14

Description: Prof Kahilu Kajimo-Shakantu Tags: Prof Kahilu Kajimo-Shakantu 

From the left: Prof Danie Vermeulen, Dean of the
Faculty of Natural and Agricultural Sciences;
Prof Kahilu Kajimo-Shakantu, Head of the Department
of Quantity Surveying and Construction Management;
Prof Francis Petersen, Rector and Vice-Chancellor
at the UFS; and Dr Franco Geminiani, chairing the
panel from the South African Council for the Project
and Construction Management Professions.
Photo: Leonie Bolleurs

Achieving programme accreditation from the respective professional bodies is the ultimate goal for the Department of Quantity Surveying and Construction Management at the University of the Free State (UFS). This is according to Prof Kahilu Kajimo-Shakantu, the head of this department. This hallmark of quality reflects the university’s aspiration towards excellence.

Construction Management programmes reviewed
The university recently received a visit by a panel, representing the South African Council for the Project and Construction Management Professions (SACPCMP) to re-accredit programmes offered by the Department of Quantity Surveying and Construction Management. During the accreditation visit, the panel evaluated the programmes to determine whether they met the minimum requirements according to a set of pre-determined criteria.

When reviewing the programmes: BSc and BSc Hons Construction Management respectively, as well as the Project Management stream of the Masters programme in Land and Property Development Management (MLPM), the panel looked at programme design and outcomes including curriculum, study material and exam papers, institutional support, student recruitment, admission, development, retention and throughput, staffing recruitment and development, teaching and learning strategies, quality assurance, facilities, infrastructure and resources, professional development, industry and practical exposure and postgraduate policies, procedures and regulations, including research activities.

If the minimum requirements are achieved, the Department of Quantity Surveying and Construction Management at the UFS will receive accreditation for its programmes from 1 April 2017 to 31 March 2022.

It will also mean that we are certified
as producing quality employable
graduates who are well prepared to
enter the industry and make a difference.

Currently, the department has full accreditation by the SACPCMP (until March 2017) and the SACQSP (until December 2017).

Later this month, a panel from the South African Council for Property Valuation Profession (SACPVP) will review the accreditation of the Valuation stream of the MLPM programme. The South African Council for Quantity Surveying Profession responsible for accrediting the Quantity Surveying programmes will visit the university in 2018.

Certified as producing quality students

Prof Kajimo-Shakantu said: “If we maintain our accreditation, it will reflect that the UFS is among the best, with programmes which are recognised by professional bodies that set competence standards for professional registration of students. It will also mean that we are certified as producing quality employable graduates who are well prepared to enter the industry and make a difference. The programmes contribute to the development of the much-needed critical skills in the built environment.”


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