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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Mpofu-Walsh inspires with music, word, and wisdom
2017-08-22

Description: TEDxUFS   Tags: TEDxUFS

Sizwe Mpofu-Walsh shared with the audience the
creative process of writing a song at the 2017
TEDxUFS conference.
Photo: Voxomnia

“Sometimes it’s the parts of us that give us the most agony, the parts of us that we think we need to change to conform to other people’s expectations, which are actually the gateways which allow us to make an impact in the world.”

This encouragement from Sizwe Mpofu-Walsh was one of the highlights of the 2017 TEDxUFS conference. According to the author, musician, and activist, we should embrace every part of ourselves. We should understand that the way in which each of us can change the world, is by becoming one with all the different parts of us which people think can’t come together.

Audience hears project for first time

For the first time ever, Sizwe shared material from his project Democracy and delusionwith an audience at the 4th annual TEDxUFS conference in the Odeion Theatre at the University of the Free State on 5 August 2017. Other speakers included the likes of Murendeni Mafumo, founder of Gentle Giant, and Elijah Djan, CEO and inventor of Nubrix.

The event also included TEDx videos, breath-taking performances, and cutting-edge technological exhibitions. The theme was Prism of Possibilities.

Launching a book and album together

Sizwe shared how he, while studying at the University of Oxford, embarked on an ambitious project where he combined his passion for academics and music: To release a book and album about the same things at the same time.

The project is a reflection of the political landscape in South Africa. Sizwe showed how he created a song about student protests by putting different layers of music together.

“The only way to do something that will leave you truly remembered is to do something different. It is to take all of yourself and pour it into the creative pursuit that you produce.”

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