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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Student leaders take the lead by launching SRC Fund

2017-08-24

The Student Representative Council (SRC) launched the SRC Fund
at a Business Breakfast on the Bloemfontein Campus.
Photo: Johan Roux

The Student Representative Council (SRC) is not just asking for financial help, but is taking the lead by launching the SRC Fund. According to different guest speakers at a recent SRC Business Breakfast, the student leadership of the University of the Free State (UFS) is setting an example.
“They (the SRC) are saying to us and to you: We are not just saying that we want free education in our lifetime. We are also prepared to assist government in assisting universities however we can in that direction,” says Pura Mgolombane, Dean of Student Affairs at the UFS.

Objectives of fund
The SRC launched the SRC Fund on 4 August 2017 at the Centenary Complex on the Bloemfontein Campus in order to fight against financial exclusion of students. The fund aims to centre all forms of fundraising initiatives by students, decreasing financial barriers to UFS entry, and utilising and maximising networks within business enterprise, former SRC members, alumni, and student fundraising initiatives. It also wants to help with the creation of exposure and mentorship programmes, funds to assist with registration and financial exclusions, entrepreneur development, partnership opportunities, and increasing employment opportunities.
Initiatives such as Right2Learn will in future form part of the fund, and fundraising initiatives such as The Cycle Tour and Kovsies Biggest Braai has also been launched.

Internal and external partnerships
Prof Nicky Morgan, Vice-Rector: Operations at the UFS, says the SRC leadership is not just asking for money. He says they are a “can do leadership” who is asking others to help them to be successful. He also stressed the important relationship between the university and the city and asked that they should work together.
Sikhululekile Luwaca, President of the Bloemfontein SRC, said the SRC wants to “build internal and external partnerships, because universities are microcosms of society”.
“We cannot do it alone and that is why we are trying to bring the business part of it, the corporate enterprise, to also assist the SRC Fund to become sustainable.”

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