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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

National Human Trafficking Resource Line a victim-centred approach to combating crime
2017-08-24

Description: Beatri Kruger Tags: Beatri Kruger 

Prof Beatri Kruger, Adjunct Professor at the
UFS Faculty of Law. Photo: Supplied

As a response to the rising number of human trafficking cases in South Africa and around the world, key role players in various fields have pulled together to come up with workable solutions on how to stop the crime and assist victims. Some of the work being done by NGOs and law enforcement agencies has been supported by insights from research conducted in communities and by academic institutions. According to Prof Beatri Kruger, Adjunct Professor of Law in the Faculty of Law at the University of the Free State and experienced researcher in human trafficking, support for victims has grown in leaps and bounds with the help of the latest technology. More and better quality information can be collected to strengthen efforts of combating the crime,” she said.

One such technological development is the national Human Trafficking Resource Line, which provides various services, including information on trafficking activities, assistance to agencies working with victims of trafficking in persons (TIP), creating a network from which data can be collected, analysed, and activities tracked, in order to ensure the best service to victims.

The resource line connects callers, often victims of TIP or anonymous tippers, to service providers in social services, law enforcement, places of safety, medical facilities, and government agencies, especially during emergencies. 

Resource line a helping hand to victims

The resource line was established in 2016 and has replaced the previous helpline. This line provides more services and resources than just a helpline. Through partnerships, it works to strengthen local and national structures that can assist victims over the phone. 

Call specialists are trained by Polaris, an American company using international standards and protocols. The call specialists are available 24/7 to take reports of human trafficking confidentially and anonymously. They put victims in touch with service providers for health screening, counselling, and repatriation if they are from another country, and also assist with case management.

Empowering service providers is the key to success

Support for service providers such as NGOs, safe houses, and government departments in the network is in the form of skills training programmes for staff, and a referral system in various provinces around the country. There are good referral partners in each province, as well as provincial coordinators ensuring accountability regarding cases, mobilising services for victims, and coordinating the referrals and response.  

To strengthen the network further, services provided in each province are being standardised to ensure that the right people are contacted when handling cases, and that key stakeholders in each province are used. The strength of the provincial provider network is key to offering victims of human trafficking the services they need.

Human trafficking is a crime that permeates multiple academic disciplines and professions. Therefore, information collected from victims through such a helpline and collated by agencies, will assist academic institutions such as the UFS in furthering their research, while strengthening the content of academic programmes in fields such as law, law enforcement, social sciences, health sciences, and international relations.

The number to call for reporting or providing tips on TIP-related crimes and activities, is 0800 222 777.

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