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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

From lock to SA prop in six months
2017-08-29

 Description: Kwenzo Bloze Tags: Kwenzo Blose, KovsieSport’s, Junior Sportsman of 2016, World Championship, Shimla 

One of the rugby players that Kwenzo Blose looks
up to, is the Cheetah prop Ox Nche. He and Nche
are both residents of the Vishuis men’s residence.
Photo: Jóhann Thormählen


If someone told Kwenzo Blose of Glenwood High School that he would scrum as prop for the South African U/20 rugby team at the Junior World Championship, he would probably have thought it was a joke. At that time he still played lock, but only six months after the shift to prop, he represented his country at the tournament in Manchester, England.

Apart from this, KovsieSport’s Junior Sportsman of 2016 – who will probably be playing in his second World Championship this year, only became a Shimla in 2017. Last year he was still playing for the University of the Free State’s Young Guns.

Beast also played lock at first
André Tredoux, former UFS and Cheetah talent scout, said the Springbok prop Beast Mtawarira also played lock and flank at school. “Glenwood competed in the Wildeklawer Super Schools Tournament. Apparently coach André spotted me there and talked to Stephan Jacobs, another UFS coach. At that stage, I still played lock and they told each other that they had to get me to the Free State and convince me to play prop. I knew nothing of these plans,” said Blose.

According to this Paulpietersburg-native, who is 1,87 m tall and weighs 112 kg, he still has a lot to learn at prop. His greatest adjustments were in the scrums. “At prop you have to absorb the pressure of the rest of the pack in order to provide your team with front-foot ball,” he said. He said Jacobs, who was his Young Guns scrum coach, and Daan Human, the Cheetah scrum doctor, has helped him a lot.

An avid student off the field
Even though rugby has opened doors for the loose head who is studying LLB Law, he maintains a good balance. “The main reason why I came to university is to study. To be playing rugby and performing well is a great blessing, but I also have to prioritise and make sure that I obtain my degree.”

This year’s Junior World Championship was from 31 May to 18 June in Tbilisi, Georgia. Last year, the Baby Boks finished in a disappointing fourth place, but Blose believes they can improve on this. “If everything goes according to plan and if some of the guys are playing again, we would have something like nine players who played in the 2016 tournament.”

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