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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Societal perceptions of women in politics in Cameroon must change

2017-08-30

Prof Lilian Lem Atanga presented a lecture,
Gender, Discourse and Cognition and Implications on
Political Participation, as part of the First Humanities
and Gendered Worlds Lecture 2017.
Photo: Charl Devenish

Women have not internalised the fact that they can participate on an equal footing in politics with men. This is one of the conclusions made by Prof Lilian Lem Atanga in a study of the political participation of women in Cameroon.
“There still is a strong belief that women can’t deliver the goods (in areas such as politics),” Prof Atanga said. According to her, stereotypes were still entrenched in Africa and a lot had to be done to change societal perceptions of the role of women in politics.

Poor representation of women in politics
Prof Atanga, an associate professor at the University of Bamenda in Cameroon, was guest speaker at the First Humanities and Gendered Worlds Lecture 2017. The lecture was hosted by the Faculty of Humanities and the Centre for Africa Studies (CAS) at the University of the Free State (UFS) in the Equitas Auditorium, Bloemfontein Campus, on 3 August 2017. The title of the research fellow’s lecture at the CAS lecture was Gender, Discourse and Cognition and Implications on Political Participation.
She noted that although there had been a marked increase in the political participation of women in Cameroon, it still was insufficient. Of the 24 million people in the country, 52% were women but only 20% of the senators and 31% of parliamentarians were women.

Gender-segregated roles affect participation
And there are many reasons for this. “A lot more women still believe in gender-segregated roles and this affects their political participation.” Many men also don’t approve of women’s political participation.
In her study Prof Atanga found that stereotypes were also emphasised in the way the media in Cameroon reported on the roles of women.

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