Latest News Archive

Please select Category, Year, and then Month to display items

PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

New developments in the Faculty of Theology and Religion

2017-08-30

Bishop JM Khumalo, Apostolic Church of
Christ; Prof Fanie Snyman, Dean of the
Faculty of Theology and Religion; and
Rev Simon Galada, Wesleyan Church,
at the faculty’s official opening in
February 2017.
Photo: Eugene Seegers

At a meeting of the UFS Council last year, a name change was accepted for the Faculty of Theology, renaming it to the Faculty of Theology and Religion. This change signals openness in approach to other religions, in addition to those of Christian denominations. This is a development that took root in Europe a few years ago. Furthermore, a growing field of interest is the study of the impact religion has had and still has, even in highly secularised societies. This name change is the first of its kind in South Africa, which means that the faculty will lead the way in transformation and impact-based religious studies.

Exciting times lie ahead
Prof Fanie Snyman, Dean of the faculty, says of these refinements: “The new name and restructuring of departments will lead to a new synergy that will have an impact on our teaching and research in the faculty. Exciting times lie ahead for the Faculty of Theology and Religion!”

Apart from the change in the name of the faculty, departments within the faculty were also regrouped, with new names. The Departments of Old Testament and New Testament merged to become the Department of Old and New Testament Studies, while the Departments of Systematic Theology and Ecclesiology merged and will now be known as the Department of Historical and Constructive Theology. The former Departments of Practical Theology and Missiology became the Department of Practical and Missional Theology. The Department of Religion Studies remained unchanged to emphasise the importance of religion in South Africa and the world at large.
Error! Hyperlink reference not valid.

Distinction of theological disciplines
The rationale for these groupings is the distinction of theological disciplines in terms of the study of texts (Old and New Testament), sources (Systematic Theology and Church History), and practices (Practical Theology and Missiology). One benefit of these newly-constructed departments is that they will be more cost-effective, but the more important advantage is that this will stimulate discussion and research across the various theological disciplines.

Back

Economic and Management Sciences

Education

Health Sciences

The Humanities

Law

Natural and Agricultural Sciences

Theology and Religion

Open Distance Learning

Business School

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept