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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Photo manipulation in journalism: evil, crutch or lifebuoy?

2017-09-04

Albe Grobbelaar, veteran journalist and lecturer in the
Department of Communication Science at the UFS.
Photo: Rulanzen Martin

Since the 1800s the manipulation of photographs has been common practice, and who can forget the OJ Simpson Time magazine cover in 1994? Albe Grobbelaar, lecturer in the Department of Communication Science at the University of the Free State (UFS), asked in a special lecture on 18 August 2017 whether “Photo manipulation in Journalism” was an evil habit, a crutch or a lifebuoy.

“As a journalist I have always been interested in photography. And the principle of photo manipulation or tampering with photos, as we call it, is something that has interested me ever since,” Grobbelaar said. Photo manipulation is an area that has garnered many academic interest and is not a new trend but a practice that started in the 1830s when photos came into popular use. “It is not always done with ulterior motives, artists played with photographs to get unique effects.” Photo manipulation is not only to create fake news, but is sometimes used to convey novelty and create shock to news readers.

Different viewpoints for different circumstances
He talked about the spectrum of viewpoints on photo manipulation. Some conservative journalism schools say photos should never be retouched while other feel it is fine to tamper with pictures. “What I tried to convey in the lecture was that one should consider different circumstances differently,” Grobbelaar said. As a journalist he believes that news photos should never be manipulated.

He mentioned the example of the mugshot of OJ Simpson that the Los Angeles Police Department released to the media. “Newsweek and Time both used the photo on their front pages, but Time deliberately darkened the picture so that OJ, a black man, would appear more sinister,” Grobbelaar said. It is, however, common practice in the fashion industry to retouch images that are used in fashion magazines.

Use own judgment to validate photos
In the age of social media it has become easy to manipulate photos and which has been labelled fake news. “I would advise people to use their own judgment when validating the authenticity of photos,” Grobbelaar said. It is important to verify whether they are from a reliable news outlet.

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