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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Qwaqwa Campus announces 2017/2018 SRC
2017-09-06

Description: QQ campus SRC Tags: Qwaqwa Campus, SRC,Sasco, Prakash Naidoo 

Newly-elected SRC President, Masopha Hlalele, leading a
ceremonial walk to the SRC chambers for the first sitting
of the SRC.With him is the Director: Student Affairs,
Temba Hlasho;IEA Chairperson, Grey Magaiza; and
Campus Principal, Prof Prakash Naidoo.
Photo: Thabo Kessah


The 2017/2018 Student Representative Council (SRC) elections on the Qwaqwa Campus of the University of the Free State (UFS) have been declared free, fair, and credible. This was announced by the Chairperson of the institutional Independent Electoral Agency (IEA), Grey Magaiza, during the official announcement of the results and the hand-over ceremony held on 4 September 2017. 

“We had an average voter turnout of 52% per elective portfolio, thus making it arguably one of the highest in the country. Compared to last year, there was a 15% increase notwithstanding the 23% increase in the student population,” he said.  
In congratulating the newly-elected SRC, the Director of Student Affairs, Temba Hlasho, challenged the student leaders to leave the campus intact and fully sustainable for future generations.
“You are now faced with the mammoth task of understanding your role in developing an ethical and moral leadership that will help to sustain the university academically, financially, and beyond.”
In his response, the new SRC President, Masopha Hlalele, acknowledged the role played by the previous SRC, and said they were prepared to usher in a new phase of turning each student into a proud ambassador of the campus.

“We will be ushering in a new phase where all students will be the focus of the SRC. This will be a phase where students will not discriminate against each other, but appreciate each other’s differences and become ambassadors,” he said.

The South African Students’ Congress (Sasco) won all seven elective seats with an average of 62.5%.

Elective portfolios:

President: Masopha Hlalele 
Deputy President: Sakhile Mnguni 
Secretary General:  Mawande Mazibuko 
Treasurer General:  Mafusi Mosia 
Media and Publicity:  Khethukuthula Thusi 
Student Development and Environmental Affairs: Mbali Ndlovu 
Politics and Transformation: Promise Mofokeng

Ex officio portfolios:

Arts and Culture: Khulani Mhlongo 
Religious Affairs: Ndamulelo Muthaki, 
RAG, Community and Dialogue: Mafeka Tshabalala 
Residence and Catering Affairs: Thato Moloi  
Sports Affairs: Sibusiso Nsibande
Academic Affairs: Mamokete Tamo
Off-Campus: Khethwa Mngezi 

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