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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Oncology department celebrates 50 years of excellence

2017-09-07

The UFS Department of Oncology celebrated 50 years of
existence. Prof Louis Goedhals says that the department
is like a family that will carry and support you.
Photo: Wendy Ruth

South Africa could see an increase of 78% in the number of cancer cases by 2030 and from a global perspective, a 75% increase is expected, increasing the total incidence of all new cancer cases from 12.7 million in 2008 to 22.2 million by 2030, according to a recent study published by medical journal Lancet. According to the Cancer Association of South Africa (CANSA), more than 100 000 South Africans are diagnosed each year. It is rather comforting that the University of the Free State’s (UFS) Faculty of Health Sciences has an Oncology department that has been fighting cancer for 50 years.

Excellence over the decades
The 50-year celebration of the Department of Oncology took place at the UFS Centenary Complex on the Bloemfontein Campus on 19 August 2017. The auspicious event was attended by UFS Faculty of Health Sciences registrars, radiation oncology radiographers and professional nurses who had trained in the department over the past 50 years, as well as the current departmental staff.

Dr Alicia Sherriff, Head of the Department of Oncology welcomed the dignitaries and thanked everyone for their attendance and dedication to the department, Prof Louis Goedhals, the oldest surviving head of department, gave a summary of the 50 years. He said once you were involved with this department you became part of a family that would carry and support you. Memories were shared and friendships rekindled. The message of this department that stood the test of time was: “To cure sometimes, to relieve often, to comfort always … and to bring hope”.

UFS dignitaries reveled in the moment
Among the special guests were the Rector and Vice Chancellor, Prof Francis Petersen, Prof Gert van Zyl, Dean of Faculty of Health Sciences; the Free State MEC for Health Mr Butana Komphela, and CEO of Universitas Hospital Dr Marcus Molokomme, were invited. The function was well attended by personnel, graduates from as far as Portugal, and dignitaries from the university. There was a sense of unity and belonging among all the attendees and enthusiastic catching up over the years that have passed.

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