Latest News Archive

Please select Category, Year, and then Month to display items

PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

BAccHons students achieve A+ rating in ITC exams

2017-09-07

The lecturers of the 2016 BAccHons class: Liesel Botha,
Prof Alta Koekemoer, Prof Cobus Rossouw, Mr Kobus Swanepoel,
Dr Cornelie Crous, Prof Hentie van Wyk, and Mr Shaun Watson.
Photo: Supplied

The 2016 BAccHons students in the School of Accountancy at the University of the Free State achieved a 96% pass rate in the 2017 Initial Test of Competence (ITC) examinations of the South African Institute of Chartered Accountants (SAICA). The ITC examinations took place in January and June, and of the 49 students that partook in the examinations, 47 passed.

Prof Hentie van Wyk, Programme Director of the School of Accountancy, said with these results, the School of Accountancy ranks among the top accountancy institutions in South Africa. “The UFS is one of 14 accredited universities offering the SAICA-accredited programme,” he said.

New teaching model a success
A new teaching and learning module, which was introduced by the School of Accountancy in 2013, seemed to have fuelled the success of the students, as it is now more learner-centred and introduced more structured support to students.

The same strategies will be followed for the current 2017 intake. “We achieved an average pass rate of 84.8% over the past five years and if we can build on that, it will be an achievement of note,” says Prof Van Wyk. However, students should understand that much of these achievements are in their own hands. “After leaving the UFS, they must continue with the preparations for the ITC examinations in order to guarantee their success. The ball is actually in the students’ court,” he said.

Of the African students, 91% were successful in the national examinations, while 100% of the Thuthuka bursary students passed. The average pass rate for the past five years is as follows:

2016 96%
2015 72%
2014 80%
2013 84%
2012 92%.

Back

Economic and Management Sciences

Education

Health Sciences

The Humanities

Law

Natural and Agricultural Sciences

Theology and Religion

Open Distance Learning

Business School

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept