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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Early diagnosis of hearing loss is important

2017-09-11

Dr Magteld Smith, lecturer in the
Department of Otorhinolaryngology
at the University of the Free State (UFS)
Photo: Supplied

One of the most common, misunderstood and neglected birth defects in developing countries is hearing loss, which can most severely impair and have a dramatic impact of the quality of life the of the person with hearing loss.

This is according to Dr Magteld Smith, lecturer in the Department of Otorhinolaryngology at the University of the Free State (UFS).

“Hearing loss refers to all the different types and levels of hearing loss, from slight to profound hearing loss,” she said.

Derived from a number of retrospective studies in South Africa, it was found 17 people a day are born with hearing loss. More than 95% of those children are born to hearing parents. This estimate excludes children and adults who lost their hearing after birth.

According to Dr Smith, hearing loss strikes at the very essence of being human, because it hinders communication with others. To enable people to communicate with those with hearing loss, the university’s Department of South African Sign Language teaches students sign language. This year, the department enrolled 230 students. A number of these students are from the Faculty of Education. These students could from 2017 for the first time choose sign language as a subject.

“Studies have shown that important language skills are learned before the age of three because hearing and learning language are closely tied together. Brain development of the auditory pathways and language cortex is occurring in young children as they respond to auditory and visual language. In families that are part of deaf culture, these parents automatically sign from day one, so the baby is learning visual (sign) language, and the appropriate brain development is occurring.

Beskrywing: Doof readmore Sleutelwoorde: geboorte-afwykings, gehoorverlies, dr Magteld Smith, Departement Otorinolaringologie

About 230 students are enrolled for the subject, South African
Sign Language, at the UFS. As an assignment some of the students
were asked to design posters to create deaf awareness among
others on campus. From the left are: Poleliso Mpahane,
Masajin Koalepe, Ntshitsa Mosase, and Zoleka Ncamane.
Photo: Leonie Bolleurs

“However, if a child has an undiagnosed hearing loss and the parents are unaware, the child will not receive the needed language stimulation — and the hoped-for development won’t take place. It is critical to understand that children with hearing loss have their own talents, different levels of intelligence, socioeconomic circumstances and different abilities, just like hearing children. Therefore, one size does not fit all,” Dr Smith said.

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