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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

International Bible scholars attend conference on Apocalyptic Literature and Mysticism
2017-09-18

Description: Bible Scholars Tags: Bible Scholars, UFS Faculty of Theology and Religion, Prof Francis Petersen 

Prof Francis Petersen, UFS Rector and Vice-Chancellor,
second from left, flanked by three
deans of theology: Prof Fanie Snyman (UFS),
Prof Jörg Frey (University of Zurich),
and Prof Gregory Sterling (Yale Divinity School).
Photo: Eugene Seegers


Apocalypticism and mysticism have become two key areas of research that have converged to form the heart of contemporary spirituality. It was with this in mind that leading local and international Bible scholars were invited to a collaborative international conference jointly hosted by the UFS Faculty of Theology and Religion and Yale Divinity School, with the theme Apocalyptic Literature and Mysticism—Investigating a Turn in Recent Apocalyptic Research.

It is perhaps unknown to many that a number of the most profound thinkers, both of Judeo-Christian tradition and other religions in general, were mystics. Their lives and writings speak of a longing for an intimate relationship with God, reflecting on universal existential questions such as understanding our human existence, our creation, and ultimately, the meaning of life.

Apocalypticism, on the other hand, focuses on texts and prophecies describing how an alternative, future world might replace our existing one, a process often cataclysmic in nature, thus, like the mystics, also reflecting on the deeper foundations of human existence and our possible demise.

Traditionally, both have been misunderstood and controversial, but more recent research has revealed their formative role in religious discourses, with many scholars finding growing commonalities between apocalyptic and mystical texts. Moreover, these commonalities help to establish a better understanding of Judeo-Christian traditions, as well as other religions in general.

This hugely successful UFS collaborative effort, as well as others of its kind, contribute to the growth of theology as a discipline, with a positive impact on the broader religious community, the church, and society as a whole in the common desire for a just, equitable, and humane world.

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