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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS hosts the 2017 SAIMS Conference

2017-09-21

The hosts of the 2017 SAIMS conference:
Dr Jacques Nel
(UFS:Business Management), Prof Francis Petersen
(UFS Rector and Vice-Chancellor),
Dr Werner Vermeulen (HOD of UFS: Business Management),
Dr Habofanwe Koloba (UFS: Business Management),
and Prof Hendri Kroukamp
(UFS: Dean of Economic and Management Sciences).
Photo: Supplied

The University of the Free State’s (UFS) Department of Business Management recently hosted the 29th South African Institute of Management Scientists (SAIMS) conference at Kopano Nokeng in Bloemfontein. This year’s theme, ‘Management Research: Science Serving Practice’ focused on the importance of sharing our results and making it relevant and usable to different communities.

Prof Petersen motivates researchers to become part of the business cycle
On the first day of the conference, the Rector and Vice-Chancellor of the UFS, Prof Francis Peterson, welcomed 148 delegates from 18 different institutions (academic and professional) to the City of Roses. He motivated them to keep on doing highly scholarly research by being part of the business cycles.

Prof Adré Schreuder, founder of Consulta (Pty) Ltd, was the keynote speaker of the conference. He highlighted four personas needed to further enhance and develop the science-practice alignment in market research and business. “The first skills persona is called a Social Media Maven, which is in line with the rapid growth of social media networks and the growing need for social media analytics. Then there is the Data Synthesiser that supports the growth trend in Big Data and Advanced analytics, which are both driven by technological innovation and the enormous volume of available data. The third one is Marketing Strategist, which has strong representation in brand and advertising research in our industry. Lastly, we have the ‘Business Consultant’ which aligns with the industry trends towards deeper insights and consultative skills required to move beyond mere reporting, but rather getting involved in the design and implementation of recommendations.”

Conference to collaborate academics and business
Dr Werner Vermeulen, SAIMS 2017 Conference Chair, says, “This conference will underpin the need for collaboration and cooperation of individuals from the academic environment and the business world itself.” He says the conference will also provide a wonderful forum to refresh knowledge and explore contemporary trends and future-based business research.

Delegates were also given the opportunity to dress up to the carnival theme and were entertained by a fire dancer and magician. They had the honour of indulging in two Kovsie-produced food products, the St Dairy organic cheese and exotic mushrooms by Mushroom House.

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