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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Fun and camaraderie key to Vishuis rugby success
2017-09-27

Description: TEDxUFS   Tags: TEDxUFS

The forwards of Vishuis laid a strong foundation in
the K1 rugby final against Kagiso. This helped them
to secure a win of 38-16.
Photo: Marelize van Niekerk

They have not only been dominating the residence rugby scene at the University of the Free State over the past few years, but also nationally. Although they might experience added pressure as favourites, a key ingredient to Vishuis’ success story is their enjoyment of the game and their camaraderie.

According to Henco Posthumus, the Vishuis captain, they realise that it still remains residence rugby. “The guys pitch up at practice because they want to play, not because somebody begged them to.”

Comfortable triumph in final

Vishuis claimed their fifth Varsity Cup Koshuis title earlier this year, and will defend their national title after being crowned Kovsie residence champions on 8 September 2017. They beat Kagiso comfortably 38-16 in the K1 final, after leading by 31-9 at half-time.

Posthumus says the fun element is often forgotten, but not at Vishuis. He says it is not just about the first team either. “Almost every house member, no matter if he studies medicine or if he hasn’t played rugby before, is playing a bit of rugby on a Friday evening. That is also why we, as a fairly small residence, can field five teams.”

More than just a game

Although their proud record serves as motivation, it is about more than just rugby. “The guys grow together in different ways. It is an honour to see how they grow during a season, also spiritually.”

They have been lucky not to suffer many serious injuries over a number of seasons, Posthumus says. “We are privileged to have 110 years of history behind our residence, and people from within and outside buy into who we are.”

“Our (new) coach, Zane Botha, is also a valuable acquisition. He has taken our rugby to the next level.”

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