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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Compassion improves psychological well-being and reduces emotional distress
2017-09-27

Description: TEDxUFS   Tags: TEDxUFS

Participants in the Kindness Project sharing a
Random Act of Kindness with the cleaning staff,
Mathabiso Sehlabaka and Madineo Mokoena.
Photo: Thabo Kessah

Various studies have reported that the cultivation and practice of compassion may result in improved self-esteem, a decrease in depression and anxiety, increase in subjective well-being, and overall improvement in physical and psychological health. This is according to Counselling Psychologist, Tobias van den Bergh, during the Kindness Project (KP) on the Qwaqwa Campus.

“Students that are involved in this project have shown statistically significant improvements in overall well-being and compassion towards themselves and others,” said Van den Bergh, the project leader and Head of Department: Student Counselling and Development, Qwaqwa Campus.

“In addition, student participants of the compassion-based intervention showed a decrease in their experience of debilitating emotions and depressive symptoms, as well as a significant increase in measurements of positive affect (an indication of life vitality), self-compassion, and well-being. Humans appear to be genetically programmed to be kind. Studies have shown that the same brain structures that are activated when we procreate (i.e. have sex) or eat chocolates, are activated when we are kind. Thus, it means showing an instinctive predisposition towards compassion for our kin and others. Kindness also appears to be contagious. Whenever we observe kindness or experience kindness ourselves, we are much more likely to be compassionate towards our fellow human beings,” he said.

The KP is based on the Science of Compassion, with participants completing a four-week compassion-based intervention where they learned about and practised self-compassion and compassion towards others. In the last week of the programme, participants completed various Random Acts of Kindness off and on the campus.

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