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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Asive humbled by new responsibility
2017-09-27

Description: TEDxUFS   Tags: TEDxUFS

Asive Dlanjwa, President of the Student Representative
Council (SRC) on the Bloemfontein Campus, and Pura
Mgolombane, Dean of Student Affairs, during the
announcement of the 2017/2018 SRC.
Photo: Johan Roux

Nothing humbles him more than the fact that thousands of students had chosen to put their weight, hopes, and dreams behind him. The emotions Asive Dlanjwa felt when he was announced as the new President of the Student Representative Council (SRC) on the Bloemfontein Campus reveals something about his character.

He clearly understands the weight of the responsibility on his shoulders. Asive, who loves the church and cycling, says he felt a variety of emotions when he was announced as president on 31 August 2017 at the Thakaneng Bridge.

“It was an exciting feeling, but more than anything, it was such a humbling feeling; humbled not only by the excitement of the students when I was announced, but also by the fact that thousands of students had chosen to put their weight, hopes, and dreams behind me!”

Two main objectives

Asive and his SRC have two main objectives – to improve access to the university and advance the integration of our off-campus students into the greater campus community. The Bachelor of Commerce student from Umtata says there are several issues and initiatives his SRC will be tackling – all of them flowing from these objectives.

Including off-campus students

Asive says the SRC will seek to improve access to the university and its various offerings, and to also provide the necessary support to ensure their success. “Also within this objective would be to decisively deal with all forms of exclusion, from academic to financial to social and cultural exclusions perpetuated by systems and policies.”

With regards to off-campus students, he says university life previously revolved around residence life. He means the remains of that are still evident, to the detriment of the greater student community who are off-campus students.

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