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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

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UFS DiMTEC will help compile national emergency management system
2017-10-11

Description: UFS DiMTEC will help compile national emergency management system Tags: UFS DiMTEC will help compile national emergency management system

Preparedness and response are the two most important aspects of managing disaster when it strikes. Prof Andries Jordaan, Head of the Disaster Management Training and Education Centre for Africa (DiMTEC) at the University of the Free State (UFS) recently attended an incident command course in California in the US.

Learning from US disaster management systems
More than 20 specialists from 17 countries attended the course where participants were introduced to the National Incident Management System (NIMS) in the US. The system was implemented after lessons learned during 9/11. “According to the NIMS structure, all government organisations at all levels as well as emergency agencies had to standardise terminology and systems,” said Prof Jordaan.

The professor also had the opportunity to visit among others the Federal Emergency Management (FEMA) headquarters in California, some State Coordination Centres as well as several other disaster management centres. He also had the chance to shadow an Incident Management Team (IMT) during active operations.

Providing training for local disaster management
Insight gained during this course, as well as Prof Jordaan’s experience as senior officer in the South African National Defence Reserve Forces, provided him the necessary background to conduct training and give assistance in terms of disaster management.

Through DiMTEC Prof Jordaan will assist the National Disaster Management Centre with the implementation of a national emergency management system. He will also provide training for incident management teams.

“DiMTEC is currently also in the process of developing a Master module in disaster response. Command and control and Incident Command will form a sub-module in the disaster response module,” he said.

From South Africa, Prof Jordaan was joined on the course by General Elias Mpumelelo Mahlabane from the South African Police Services, who is responsible for disaster management in the SAPS. Savage Breytenbach, a trainer in rural fire fighting who assists Mangaung with command and control structures, also attended the course.

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