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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

New schools, restructuring part of streamlined Faculty of Health Sciences

2017-10-12

From the left, front are: Dr Jocelyn Naicker,
Prof Gert van Zyl, Prof Magda Mulder;
back from left: Prof Chris Viljoen,
Marlene Viljoen, Deputy Director: Faculty of Health Sciences;
Prof Nathaniel Mofolo; and Prof Santie van Vuuren.
Photo: Rulanzen Martin

Numerous developments, such as the creation of two new schools and one newly restructured School of Medicine in the Faculty of Health Sciences at the University of the Free State (UFS), will catapult this renowned faculty to even greater heights.

Five-school structure to increase access
A five-school structure was proposed at the annual Faculty Management retreat in July 2016. The previous three-school model included the Schools of Medicine, Nursing, and Allied Health Professions.

The current School of Medicine has been restructured and will henceforth be known as the School of Clinical Medicine. The Schools of Pathology and Biomedical Sciences have been added to the faculty. “So, three new schools were in fact created within the faculty,” said Prof Gert van Zyl, Dean of the faculty.

“There was also a request from the National Health Laboratory Services to group academics that is rendering services in pathology into a new School of Pathology.” This is what motivated the faculty management to create two new schools.

Esteemed academics appointed
With the creation of the new schools, there were also new appointments within the Faculty of Health Sciences. Dr Jocelyn Naicker has been appointed as the new part-time Head of the School of Pathology, Prof Chris Viljoen was appointed as the part-time Head of the School of Biomedical Sciences, and Prof Nathaniel Mofolo as the new Head of the School of Clinical Medicine. Prof Santie van Vuuren remains Head of the School of Allied Health Professions, and Prof Magda Mulder as the head of the School of Nursing.

Research outputs to remain as usual
The addition of the new schools will not impact research output. “In the past, research was done across departmental boundaries between all the departments in the faculty,” Prof Van Zyl said. The advantages of adding two additional schools are that the workload will be distributed among the five schools. The heads of schools will work within their respective disciplines and related areas, and will eliminate the duplication of administrative functions.

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