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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Luvo and Ryk inspire UFS student leaders

2017-10-13

Ryk Neethling and Luvo Manyonga have a special bond.
The sporting duo shared their inspiring stories with student
Leaders of the University of the Free State.
Photo: Kaleidoscope Studios

Dreams can come true and Luvo Manyonga’s story is the perfect example. It would make the ideal movie script. This is opinion of the businessman and former international swimmer Ryk Neethling.

The Olympic gold medallist and former World Champion and Manyonga shared their stories with new student leaders of the University of the Free State (UFS).

“I am so proud of this guy,” Neethling said. “And we are just half-way through this movie. The best is yet to come.” The 26-year-old Manyonga is the current Olympic silver medallist and World Champion in long jump. But he had to overcome huge obstacles as a former tik or crystal meth addict.

Not an easy road
The duo were guests for a session, Inspirational Stories of Lived Humanising Experiences, which was part of the university’s Student Leadership Training weekend for Student Representative Councils, Residence committees, Residence Assistants and Association Representatives in the Economic and Management Sciences Auditorium on the Bloemfontein Campus.

Manyonga, who is dating the Kovsie netball player Khomotso Mamburu, talked about growing up in Mbekweni township in Paarl, about his career and his setbacks.

After finishing fifth at the IAAF World Championships in Daegu, South Korea, in 2011 he started partying when he returned home. “I hooked up with the wrong friends and they introduced me to tik,” he said. “They told me: ‘Hey dude, you are drunk. Just take a hit and it will sober you up.’ I took it and it was nice, but that is where it started.”

Be surrounded by positive people
Manyonga lost all his money and his sport was also suffering because of his addiction. “At the beginning of 2014 I started to realise that I was throwing my life away and I needed help. I went to reach out to people close to me and told them I had a problem.” He thanked Neethling, who helped him when he was at his lowest, his mother, the South African Sports Confederation and Olympic Committee, Tuks Sport and the High Performance Centre where he trains for the influence on his life.

Neethling’s advice to student leaders was to dream big, work hard, expand your network and find a mentor you can learn from.

“Always surround yourself with positive people,” he said. “You can succeed if you stay positive.”

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