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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS ICT Services mentioned among global PeopleSoft pioneers
2017-10-23

 Description: Andrew read more Tags: ICT services, technology, innovations, PeopleSoft, Oracle, students, IT, awards 

Andrew Jusjong, Chief Officer: ICT, one of the main drivers
of PeopleSoft at the UFS. 
Photo: Rulanzen Martin

At the beginning of his term, the Rector and Vice-Chancellor of the University of the Free State (UFS), Prof Francis Petersen, mentioned to parents and prospective students the importance of the UFS being recognised globally as innovators. 

This month, Information and Communication Technology Services (ICT Services) were recognised by Oracle as one of the PeopleSoft Innovators at the Oracle OpenWorld (an international conference regarding all Oracle products) for deploying student self-service, using PeopleSoft Campus Solutions’ new Fluid user interface.  

Andrew Jusjong, Chief Officer: ICT, says, “This solution allows dynamic administrative setup regarding available degrees, customised messages, dynamic required degree-specific documentation, and integration with the Applications and Admissions module.”  He says it also includes self-service functionality that allows students to track the status of their applications, and provide additional documentation required for their study choices.

“The UFS is the only innovator in the European, Middle-Eastern and African region. Considering that the development team at the UFS is much smaller than their international counterparts, this illustrates that we do not have to stand back for our international peers regarding service delivery and the quality of service to our customers,” he says.

The PeopleSoft Innovator awards are presented to companies that are taking advantage of the latest capabilities and technologies provided by Oracle PeopleSoft in order to transform their businesses and their IT practices, while also providing benefits to the business and end users. The UFS has been making use of PeopleSoft applications since 2004. It currently makes use of three applications:

- PeopleSoft Financials for procurement, budgeting, billing, asset management, general ledger, journals, provisioning, payroll, commitment control, ad hoc claims, travel and expenses, and maintenance management.
- PeopleSoft Human Capital Management for HR data processes, recruitment, workforce management, remuneration management, leave management, employee self-service, and other HR activities; and 
- PeopleSoft Campus Solutions for student lifecycle management, applications and admissions, curriculum management, programme enrolment, student records, student financials (accounts), financial aid, graduation, alumni management, graduate research management, residences, and student self-service.

In the Higher Education sector, PeopleSoft is being used by over 900 campuses in 34 countries, across six continents. “This means that recognition was given to the university on a global platform,” says Jusjong.

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