Latest News Archive

Please select Category, Year, and then Month to display items

PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Kovsie Dux student seeks to help farmers through her research

2017-10-24

Chéri-Lynn Steyn, the Kovsie Dux student for 2016/2017,
likes going on game drives in the Kruger National Park
and taking photographs of birds with her brothers.
Photo: Jóhann Thormählen

From failing her first test at university to becoming the Kovsie Dux; from being a first-year in a tutor class to becoming a tutor these are snippets from Chéri-Lynn Steyn’s journey at the University of the Free State (UFS).

Although she was not accepted into Medical School to pursue her childhood dream of studying Medicine, she has never looked back and now wants to guide farmers on how to be more efficient and sustainable.

Steyn, who studies BScAgric Animal Science and Agricultural Economics, was crowned the Kovsie Dux Student for 2016/2017. The award recognises and rewards the top-performing and all-round brilliant student. The criteria are a high academic average, coupled with excellent participation and excellence in extra-curricular activities like Community Service, Culture, Leadership and Sports.

Overcoming obstacles a highlight
The Research Assistant at Agricultural Economics says she cannot believe she is the winner. After three years at university, her CV includes 29 modules and 29 distinctions, but she is a well-balanced individual. She has been on the Agricultural Committee, First-Years Committee at Wag-'n-Bietjie residence, a class representative, is an interprovincial hockey umpire, and has cycled the Cape Town Cycle Tour and Telkom 94.7 Cycle Challenge.

Steyn recently looked back at her UFS journey: “From a layman who knew nothing about the agricultural industry, to someone who is able to understand and join in conversations about the industry,” she says. “My personal highlights are those small significant moments of overcoming obstacles.”

Effort less when you love what you do
She says her success is through grace and the Lord’s strength. “I endeavour to never compare myself to others, but set the standard against myself. This enables me to push myself harder and further than I did previously.”

Steyn also feels that when you love what you do, putting in a lot of effort is no effort at all. “My big dream is to be able to help farmers on a large scale through the research I do.”

Back

Economic and Management Sciences

Education

Health Sciences

The Humanities

Law

Natural and Agricultural Sciences

Theology and Religion

Open Distance Learning

Business School

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept