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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Two UFS architecture students won prestigious PG Bison 1.618 Competition
2017-10-26

 Description: Bison read more Tags: : Stephan Diedericks, Department of Architecture, Margaux Loubser, Kobus du Preez, Zack Wessels, PG Bison 1.168 Competition 

At the PG Bison 1.618 competition awards ceremony
in Rosebank, were from the left:
Camrin Plaatjes from the University of KwaZulu-Natal;
Stephan Diedericks, winner of the competition;
and Margaux Loubser,
the second-place winner. Both Stephan and
Margaux are studying Architecture at the UFS.
Photo: Supplied



Food that reaches its sell-by date in supermarkets is usually disposed of, but has not yet reached its best-before date.  What happens to this food?  According to Stephan Diedericks, the answer to this is for this food to be repurposed.

Not only does Stephan want to prevent the waste of food – in a world where food security is a challenge – but he also won the prestigious PG Bison 1.618 Competition with his entry in which he suggests that gourmet meals be prepared from food that has reached its sell-by date, and then be served in the Delta Recycletorium. 

Students introduced to park lands in urban areas
Diedericks is a student in the Department of Architecture at the University of the Free State (UFS). Second-place winner in this competition was Margaux Loubser, also a UFS student. Another UFS student, Dehan Kassimatis, was a finalist. They received their awards at a ceremony in Rosebank, Johannesburg, earlier this month. 

The competition, now in its 24th year, was created to recognise the future interior and industrial designers, architects, and key decision-makers in the South African construction industry. It is known not only for the prestige it offers its winners, but also for the tradition-defying brief given to the students each year.

According to lecturers Kobus du Preez and Zak Wessels, in the Department of Architecture, the competition introduced the students to parklands in urban areas. He quotes the competition brief: “Rural to urban migration with the development of commercial and residential property elevates the importance of parklands within cities, in creating a refuge from the hustle of daily life.  These areas are leveraged to encourage healthier living, community interaction and environmental awareness.”

Learning experience more important than prizes
The site that was the focus of the competition is the Environmental Centre, Delta Park Heritage Precinct in Johannesburg. Students needed to transform this old building into a vibrant gastronomic restaurant. “The theme and style of the restaurant was for the student to choose,” said Du Preez. 

Loubser called her restaurant Rooted – a wholefood restaurant.  She was influenced by the geometries of the original Art Deco building. Rooted articulates and integrates the space between nature and the building.  Similar to an Art Deco painting or poster, the landscape is abstracted into terraces which are used to grow vegetables organically.  Vertical green screens soften the divide between the building and its surroundings and it provides shade.

“Our students took their clues from the existing environment and integrated it with a single idea, an abstract concept, which impressed the judges,” Du Preez said. 

Although this is a competition that is well reported in the industry press, Du Preez and Wessels agree that the learning experience for students is much more important than winning the contest. The competition’s brief aligned well with the Department of Architecture’s learning content with its urban focus.

Jacques Steyn, a UFS architecture student, came third in the competition in 2015.

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