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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Newton Fellow at UFS focuses on land and labour

2017-10-28

Dr Rory Pilossof
Photo: Charl Devenish

Dr Rory Pilossof is a senior lecturer in economics at the University of the Free State (UFS), a Postdoctoral Fellow at the International Studies Group at UFS, and a Research Fellow at the University of Kent in the UK.

He became interested in his research field when he studied land reform and land issues in Zimbabwe for his PhD at the University of Sheffield. From there, his research interests have expanded to look at other issues connected to land, such as whiteness and labour.

Dr Pilossof's study field links up with the important issue of land reform in Southern Africa due to its past colonialism and post-colonial politics of land and land ownership. These intersect with a wide range of labour issues that are pressing in the region. He has a keen interest in elite transitions and changes in economic structure in Southern Africa since the 1960s.

Dr Pilossof was nominated to the South African Young Academy of Science in 2017, and received an NRF Y1 rating during 2017. He is also a member of the Amsterdam-based International Institute for Social History’s ‘Global Collaboratory on the History of Labour Relations’. He is a participant in the Leverhulme Trust-funded initiative ‘Comparative History of Political Engagement in Western and African Societies Programme’ at the University of Sheffield.

Dr Pilossof's primary research focuses on issues of land, labour and changing social and economic structures in Zimbabwe and South Africa. He is also interested in finding alternative ways of looking at change. To this end, he has studied various newspapers and periodicals in the region.

Currently, he spends most of his research time as part of a three-year British Academy-funded Advanced Newton Fellowship into labour relations and occupational structures. In future, he wants to expand his research in the labour field by looking at labour and migration in the region over the course of the 20th century.

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