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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Tactile paving assists visually impaired

2017-10-28

Description: ' 000 Blind Tactile Paving Tags: Blind Tactile Paving

Tactile paving is being installed at pedestrian crossings to assist
visually-impaired persons at the UFS.
Photo: Supplied

Crossing roads and accessing buildings has always been a challenge for people with visual impairments. They had to rely on peripheral sounds, such as car brakes and cues. However, after the installation of tactile paving – paving with special textures assisting the visually impaired to feel the difference between walking around on campus and crossing the road, this will no longer be a problem at the University of the Free State (UFS).

This is one of several developments that University Estates’ Department of Facilities Planning has in the pipeline for 2017 in order to ensure that the university attains its key component in providing a high-quality student experience.

Maureen Khati, Assistant Director of Project Management: Facilities Planning, says, “We saw the need to install these paving blocks in strategic spaces, as identified by the Center for Universal Access and Disability Support (CUADS).” She says these blocks will make it easier for people with visual impairments.

Special features designed to aid visually-impaired persons

These installations have special features that will assist those students and employees with limited vision or blindness to navigate through pedestrian crossings and the different campus buildings. The university chose a unique design of tactile paving that focuses on warning and directing those with visual impairments.

UFS eager to improve accessibility and mobility

The university, and all the stakeholders involved in this initiative, are delighted to be embarking on this project and are looking forward to its successful execution. To improve accessibility and mobility, more accessible entrances and exits will be built, effective signage will be installed inside and outside buildings, but the most important aspect is that dedicated seating space will be made available in lecture rooms for special-needs students.

Khati says, “More focus has been put on installing ramps in all buildings to make them more accessible for people with disabilities, as well as other needs required to enhance accessibility at the UFS.”

For the UFS, this initiative is one of many to come, as extensive research is being done and priorities are implemented accordingly.

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