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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Art and science help us understand the world and our place in it
2017-10-28



Description: Art and science  Tags: Art and science

At the event were, from the left: Tristan Nel, first-year Fine Arts student;
Dr Janine Allen-Spies from the Department of Fine Arts;
Prof Carlien Pohl-Albertyn from the Department of Microbiology,
Biochemical and Food Biotechnology; and Pheny Mokawane, a
Microbiology, Biochemical and Food Biotechnology student.
Photo: Charl Devenish

Although BioArt dates back as far as the 15th and 16th centuries with the work of Leonardo da Vinci, it is not every day that art and science combine. This rare phenomenon made its appearance when two totally different groups of students – studying arts and microbiology respectively – joined hands in an initiative to create BioArt.

This first-time undergraduate teaching collaboration between the Departments of Fine Arts and Microbial, Biochemical and Food Biotechnology at the University of the Free State (UFS), which is characterised by the use of living materials, such as enzymes, microbes and DNA, as well as scientific tools and methods, is exploring a number of questions. 

Different outcomes for arts and microbiology students

According to Prof Carlien Pohl-Albertyn from the Department of Microbiology, Biochemical and Food Biotechnology, one of the central questions explored in BioArt is the nature of ‘life’. “At which stage can matter be classified as being alive or living?” she asked. 

“We realised that the outcomes for the two groups of students would not be the same. For the microbiology students, the focus would be on the understanding and effective communication of a microbiological concept. For the art students the focus would be on the execution of the assignment using visual elements and applied theory of art,” said Prof Pohl-Albertyn.

Dr Janine Allen-Spies from the Department of Fine Arts added: “Art students will also be exploring strangely or previously unforeseen gaps between art and science that can be filled with imaginative interpretations which may forward creative insights in both BioArt as a developing art form and microbiology as investigative science.”

Students’ understanding of microbial evolution reflected in art
The art students had to visit the microbiology labs for their assignment as this is mostly a foreign environment for these students. “The paint medium they had to use was gouache. This medium with its bright colours works well to depict microscopic organisms in art,” Dr Allen-Spies said. 

On display at the Department of Microbial, Biochemical and Food Biotechnology on the Bloemfontein Campus, at a recent event to introduce this new initiative to a wider audience, was a range of visually and scientifically compelling paintings and artefacts (such as paintings, poems, songs, apps) which explore a theme within microbiology from a BioArt perspective that uses creativity to communicate concepts dealt with in the module Microbial Evolution and Diversity.

Any parties who are interested in buying the art can contact Dr Allen-Spies at allenj@ufs.ac.za.

Paintings and artefacts reflects students understanding of BioArt. At the recent opening of the BioArt exhibition at the UFS Department of Microbial, Biochemical and Food Biotechnology, was the work of Madeleen Jansen van Rensburg on display.

Pheny Mokawane, a Microbiology, Biochemical and Food Biotechnology student, wrote a poem for his BioArt project in the Microbial Evolution and Diversity assignment. 

 

 

 

 

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