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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

New name and format for UFS Rag

2017-11-02

The community garden project will help individual student communities
to begin and maintain their own vegetable gardens to address food insecurity
within their own environment.
Photo: Pixabay

Get ready for celebrating with a cause at the University of the Free State (UFS). After an external review and internal consultation process, our “giving back” will get a fresh new look. Our RAG, as you know it, will have a new name and format going forward.

Innovative thinking will align the UFS Student Affairs, RAG Community Services (RCS), Community Engagement (CE), and Services Learning (SL) to deliver suitable contributions for current community needs. We will guide the alignment process with an integrated framework for learning and developmental outcomes. If the RCS, CE, SL, and Student Affairs align their specific programmes and activities to achieve the same developmental outcomes, we believe that the collective effect will be enhanced. You get further if you pull in the same direction, rather than various good-intentioned movements on different routes.

Stronger together An Institutional Committee for Civic and Social Responsibility (CSR) will act as the overarching structure for accountability, alignment, and advice to the RCS, CE and SL divisions. In a collective effort, four exciting programmes will take flight.

1 Schools project for first-year students Mentored by senior students, groups of first-year students will be assigned to, and participate in local school projects. Students will learn to solve problems and work together in small groups as they collaborate on a specific community project involving primary or secondary schools in the Mangaung region.

2 Community gardens This project will help individual student communities to begin and maintain their own vegetable gardens to address food insecurity within their own environment.

3 Eco-vehicle project for senior students The aim of the eco-vehicle project is to create an interdisciplinary experience. Undergraduate senior students from a Student Life College (SLC) can work together to build an eco-vehicle from waste material. The track day, along with creative pit stops, will take place on 16 February 2018, preceding the Community celebration of 17 February 2018.

4 Community celebration To foster good relationships between the UFS and the community, we aim to host an annual celebration that will be open to the broader Mangaung community. The celebrations will kick off on the morning of 17 February 2018 with a business relay and a showcase of the eco-vehicles. The festive day will conclude with an evening music concert.

We have yet to rename “RAG”, and while this creative process is brewing, you can look forward to paying it forward with value! Any suggestions with regard to a new name for our new process can be forwarded to scheepersk@ufs.ac.za

Name suggestions will be accepted until 30 November 2017.

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