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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Discussion on decolonising the UFS draws international speakers
2017-11-07


During an insightful two days (27-28 October 2017), bright young minds and experienced thinkers came together at the University of the Free State (UFS) to engage in deep philosophical talks on the topic of decolonisation.  The event was hosted by the university’s Centre for Africa Studies and the Department of Philosophy.

Heavyweight thinkers
Attendees to this colloquium were treated to the thoughts of renowned academics from various social sciences disciplines, including: Prof Francis B. Nyamnjoh, University of Cape Town; Prof Henning Melber, Dag Hammarskjöld Foundation, Nordic Africa Institute, University of London, University of Pretoria and the UFS; Prof Heidi Hudson, UFS; Prof Sabelo J Ndlovu-Gatsheni, University South Africa; Alida Kok, Unisa; and from the UFS Prof Johann Rossouw, Dr Stephanie Cawood, Dr Christian Williams, and Khanya Motshabi. All the speakers had extensive global experience that allowed them to use practical examples to illustrate theoretical ideas. These ranged from students removing colonial spirits with African rituals, incorporating indigenous knowledge systems in curricula, to the creation of cultural houses on campuses where students can become acquainted with different cultures in a safe space.  

 

 Description: Decolonising colloquium bigger Tags: Decolonising colloquium bigger

Questions from attendees at the recent colloquium on decolonising the university,
hosted by the Centre for Africa Studies and the Departement of Philosophy,
showed a search for solutions to the current decolonising dilemma.
Photo: Charl Devenish


Where to from here?
Questions from attendees showed a search for solutions to the current decolonising dilemma. How will it look? Is it possible? Has it worked anywhere? During the two days, it became clear that colonialism reaches far and deep, rendering decolonisation a complex problem that should be addressed carefully to avoid greater divisions. “Colonisers and colonised are two sides of a coin,” Prof Melber explained. “Essentially it means that we are part of the same coin.” This metaphor illustrated how there is no right or wrong world view, or right or wrong knowledge – there should, however, be an integrated approach suitable for that “one coin”. 

It starts at home
Successful decolonisation starts in the mind, it was agreed. Colonisation robbed us all of a richness of knowledge by offering absolutes, or “the only truths”. Questioning existing colonial knowledge and exploring other bodies of knowledge will ultimately lead to a new world of knowledge. Being mediators between the different worlds of knowledge is what the new generation of academics needs to become.  

 

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