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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

South Campus delivers out-of-the-box solutions

2017-11-07

The AIO device as deployed in an IBP school.
Photo: Elrieka van Dalen

The IDEAS Lab on our South Campus supports learners in 83 schools by means of academic videos transmitted via the Internet Broadcast Project (IBP) and its own custom-built All-in-One (AIO) device. The project is a collaboration between UFS and the Department of Education in the Free State. It includes support for Mathematics, Physical Science, Life Science, Economics, Accounting, and Geography.

The AIO was purpose-built by the team at IDEAS Lab to facilitate the delivery of video lectures from highly-qualified teachers to identified schools. It comprises a projector, speakers, and a computer, which are housed in a custom-made, hard-wearing frame. The AIO is then set up at each school to which lessons are broadcast.

On-the-job training for educators

Educators have not been overlooked, either. UFS was the very first university to provide an Advanced Certificate in Teaching in a fully digital format, the ACT Online programme. It is designed for practicing teachers to upskill themselves in order to better address the needs in the classroom, not only advancing their career, but strengthening their knowledge, competencies, and subject specialisation as well. Ultimately, this leads to an improved quality of education, which has a profound impact on multitudes of students around South Africa.

CSIR joint initiative

Coupled with these projects is a new joint initiative termed ICT For Education. This project sees the CSIR collaborating with the national Department of Education, the Department of Rural Development and Land Reform, and the UFS. For this project, 24 primary and secondary schools in South Africa were identified to promote technological advancement in the education sector. Tablet computers have been allocated and already deployed at these schools, to learners as well as nearly 400 teachers.

South Campus is involved in the training of the teachers and learners in the use of the tablets in the classroom and other educational opportunities. In addition, training for 48 unemployed young people who will be providing first-line support began in March at a school in Thaba Nchu. The course on IT support is structured in such a way that anyone in the community can take it, starting out with topics such as My role in the community.

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