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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Jan Smuts: from country boy to world stage; a reassessment

2017-11-10

At the book discussion of Jan Smuts: van boerseun tot wêreldverhoog;
'n herwaardering, were from the left: Con Robinson, Protea Bookshop;
Prof Kobus du Pisani; and Prof André Wessels from the Department
of History at the UFS.
Photo: Leonie Bolleurs

Prof André Wessels from the Department of History at the University of the Free State (UFS) was one of 20 co-authors of Jan Smuts: van boerseun tot wêreldverhoog; 'n herwaardering – a book compiled under the leadership of the general editor, Prof Kobus du Pisani, from North-West University. This unique history book deals with the different themes in the life of Smuts, rather than describing the events chronologically.

South Africans are almost afraid of their own history nowadays ... and yet another history book is being launched. Does it make sense? Yes, for two reasons.

The monster in the dark
One of the ways to overcome fear is through knowledge. The monster in the dark disappears when one understands that the street lights and tree branches are creating interesting shadows. The more one knows about something, the less scary it becomes.

The Greek Bible
This was possibly also Smuts’s approach. Knowledge was his passion, and even today he is considered as one of the best students of the University of Cambridge. Although very few people really understand his holism theory, Smuts experienced the complex world in a very simple way – as one – not as lots of different pieces functioning independently of each other.

Smuts could have made a success of any of his interest fields – law, botany, literature, and philosophy. However, politics laid three wars on his doorstep. While he is regarded as a militarist by some, he was actually a peacemaker. He played a role in the establishment of the League of Nations, and later the United Nations. Incidentally, he continued to read the Greek Bible while on commando during the Anglo-Boer War.

A colourful character
The second reason for yet another Jan Smuts history book is his fascinating humanness. Time should be spent on colourful characters such as this. It is worthwhile hearing the story of someone who had such a great impact locally and internationally – good or bad.

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